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Publications

AuthorsPublication TitleJournalYear
McLaren P.J., Porreca I., Iaconis G., Mok H.P., Mukhopadhyay S., Karakoc E., Cristinelli S., Pomilla C., Bartha I., Thorball C.W., Tough R.H., Angelino P., Kiar C.S., Carstensen T., Fatumo S., Porter T., Jarvis I., Skarnes W.C., Bassett A., DeGorter M.K., Sathya Moorthy M.P., Tuff J.F., Kim E.Y., Walter M., Simons L.M. , Bashirova A., Buchbinder S., Carrington M., Cossarizza A., De Luca A., Goedert J.J., Goldstein D.B., Haas D.W., Herbeck J.T., Johnson E.O., Kaleebu P., Kilembe W., Kirk G.D., Kootstra N.A., Kral A.H., Lambotte O., Luo M., Mallal S., Martinez-Picado J., Meyer L., Miro J.M., Moodley P., Motala A.A., Mullins J.I., Nam K., Obel N., Pirie F., Plummer F.A., Poli G., Price M.A., Rauch A., Theodorou I., Trkola A., Walker B.D., Winkler C.A., Zagury J.F., Montgomery S.B., Ciuffi A., Hultquist J.F. , Wolinsky S.M., Dougan G., Lever A.M.L., Gurdasani D., Groom H., Sandhu M.S., Fellay J.Africa-specific human genetic variation near CHD1L associates with HIV-1 load Nature 2023
Soliman S.H.A., Cisneros W.J., Iwanaszko M., Aoi Y., Ganesan S., Walter M., Zeidner J.M., Mishra R.K., Kim E.Y., Wolinsky S.M., Hultquist J.F., Shilatifard A.Enhancing HIV-1 latency reversal through regulating the elongating RNA Pol II pause-release by a small-molecule disruptor of PAF1C.Science Advances2023
Vandervaart J.P., Inniss N.L., Ling-Hu T., Minasov G., Wiersum G., Rosas-Lemus M., Shuvalova L., Achenbach C.J., Hultquist J.F., Satchell K.J.F., Bachta K.E.R.Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions. Microbiology Spectrum 2023
Vaidyanathan A., Taylor H.E., Hope T.J., D'Aquila R.T., Bartom E.T., Hultquist J.F., Peter M.E.Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity Journal of Virology 2023
Fink E.A., Bardine C., Gahbauer S., Singh I., Detomasi T.C., White K., Gu S., Wan X., Chen J., Ary B., Glenn I., O'Connell J., O'Donnell H., Fajtová P., Lyu J., Vigneron S., Young N.J., Kondratov I.S., Alisoltani A., Simons L.M., Lorenzo-Redondo R., Ozer E.A., Hultquist J.F., O'Donoghue A.J., Moroz Y.S., Taunton J., Renslo A.R., Irwin J.J., García-Sastre A., Shoichet B.K., Craik C.S.Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors Protein Science 2023
Ozer E.A., Simons L.M., Adewumi O.M., Fowotade A.A., Omoruyi E.C., Adeniji J.A., Dean T.J., Zayas J, Bhimalli P.P., Ash M.K., Godzik A, Schneider J.R., Mamede J.I., Taiwo B.O., Hultquist J.F., Lorenzo-Redondo RMultiple expansions of globally uncommon SARS-CoV-2 lineages in NigeriaNature Communications2022
Malikov V., Meade Nathan., Simons L.M. , Hultquist J.F., Naghavi, M.H.FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expressionCell Reports2022
Hiatt J., Hultquist J.F., McGregor M.J., Bouhaddou M., Leenay R.T., Simons L.M., Young J.M., Haas P., Roth T.L., Tobin V., Wojcechowskyj J.A., Woo J.M., Rathore U., Cavero D.A., Shifrut E., Nguyen T.T., Haas K.M., Malik H.S., Doudna J.A., May A.P., Marson A., Krogan N.J.A functional map of HIV-host interactions in primary human T cells.Nature Communications2022
Yoh S.M., Mamede J.I., Lau D., Ahn N., Sánchez-Aparicio M.T., Temple J., Tuckwell A., Fuchs N.V., Cianci G.C., Riva L., Curry H., Yin X., Gambut S., Simons L.M., Hultquist J.F., König R., Xiong Y., García-Sastre A., Böcking T., Hope T.J., Chanda S.K.Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA.Molecular Cell2022
Johnson J.R., Crosby D.C., Hultquist J.F., Kurland A.P., Adhikary P., Li D., Marlett J., Swann J., Hüttenhain R., Verschueren E., Johnson T.L., Newton B.W., Shales M., Simon V.A., Beltrao P., Frankel A.D., Marson A., Cox J.S., Fregoso O.I., Young J.A.T., Krogan N.J.Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling.
Cell Reports2022
Packard T.A., Schwarzer R., Herzig E., Rao D., Luo X., Egedal J.H., Hsiao F., Widera M., Hultquist J.F., Grimmett Z.W., Messer R.J., Krogan N.J., Deeks S.G., Roan N.R., Dittmer U., Hasenkrug K.J., Greene W.C.CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir.mBio2022
Alisoltani A., Jaroszewski L., Godzik A., Iranzadeh A., Simons L.M., Dean T.J., Lorenzo-Redondo R., Hultquist J.F., Ozer E.A.ViralVar: A Web Tool for Multilevel Visualization of SARS-CoV-2 Genomes.Viruses2022
Ling Hu T., Rios Guzman E., Lorenzo-Redondo R., Ozer E.A., Hultquist J.F.Challenges and Opportunities for Global Genomic Surveillance Strategies in the COVID-19 Era.Viruses2022
Cisneros W.J., Cornish D., Hultquist J.F.Application of CRISPR-Cas9 Gene Editing for HIV Host Factor Discovery and Validation.Pathogens2022
Samer S., Thomas Y., Araínga M., Carter C., Shirreff L.M., Arif M.S., Avita J.M., Frank I., McRaven M.D., Thuruthiyil C.T., Heybeli V.B., Anderson M.R., Owen B., Gaisin A., Bose D., Simons L.M., Hultquist J.F., Arthos J., Cicala C., Sereti I., Santangelo P.J., Lorenzo-Redondo R., Hope T.J., Villinger F.J., Martinelli E.Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.JCI Insight2022
Rios Guzman E., Hultquist J.F..Clinical and biological consequences of respiratory syncytial virus genetic diversity.Therapeutics Advances in Infectious Disease2022
Reyna M.E., Edward P.R., Ozer E.A., Simons L.M., Hultquist J.F., Lorenzo-Redondo R., Patel A.B., Kociolek L.K.Incidence and Clinical Characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 Infection After Vaccination in Children.Journal of Pediatrics2022
Edward P.R., Lorenzo-Redondo R., Reyna M.E., Simons L.M., Hultquist J.F., Patel A.B., Ozer E.A., Muller W.J., Heald-Sargent T., McHugh M., Dean T., Dalal R.M., John J., Manz S.C., Kociolek L.K.Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study.
Journal of the Pediatric Infectious Diseases Society2022
Lorenzo-Redondo R., Ozer E.A., Hultquist J.F.Covid-19: is omicron less lethal than delta?
BMJ2022
Fernandez-de Céspedes M.V., Hoffman H.K., Carter H., Simons L.M., Naing L., Ablan S.D., Scheiblin D.A., Hultquist J.F., van Engelenburg S.B., Freed E.O.Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+ T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.Journal of Virology2022
Simons L.M., Ozer E.A., Gambut S., Dean T.J., Zhang L., Bhimalli P., Schneider J.R., Mamede J.I., Ison M.G., Karmali R., Gordon L.I., Lorenzo-Redondo R., Hultquist J.F.De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients.Transplant Infectious Diseases2022
Ke R., Martinez P.P., Smith R.L., Gibson L.L., Achenbach C.J., McFall S., Qi C., Jacob J., Dembele E., Bundy C., Simons L.M., Ozer E.A., Hultquist J.F., Lorenzo-Redondo R., Opdycke A.K., Hawkins C., Murphy R.L., Mirza A., Conte M., Gallagher N., Luo C.H., Jarrett J., Conte A., Zhou R., Farjo M., Rendon G., Fields C.J., Wang L., Fredrickson R., Baughman M.E., Chiu K.K., Choi H., Scardina K.R., Owens A.N., Broach J., Barton B., Lazar P., Robinson M.L., Mostafa H.H., Manabe Y.C., Pekosz A., McManus D.D., Brooke C.B.Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution.
Open Forum Infectious Diseases2022
Agarwal D.K., Hunt A.C., Shekhawat G.S., Carter L., Chan S., Wu K., Cao L., Baker D., Lorenzo-Redondo R., Ozer E.A., Simons L.M., Hultquist J.F., Jewett M.C., Dravid V.P.Rapid and Sensitive Detection of Antigen from SARS-CoV-2 Variants of Concern by a Multivalent Minibinder-Functionalized Nanomechanical Sensor.Analytical Chemistry2022
Lundberg A.L., Lorenzo-Redondo R., Hultquist J.F., Hawkins C.A., Ozer E.A., Welch S.B., Prasad P.V.V., Achenbach C.J., White J.I., Oehmke J.F., Murphy R.L., Havey R.J., Post L.A.Overlapping Delta and Omicron Outbreaks During the COVID-19 Pandemic: Dynamic Panel Data Estimates.
JMIR Public Health and Surveillance2022
Mithal L.B., Otero S., Simons L.M., Hultquist J.F., Miller E.S., Ozer E.A., Shanes E.D., Goldstein J.A.
Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth. Placenta 2022
Madden P.J., Thomas Y., Blair R.V., Samer S., Doyle M., Midkiff C.C., Doyle-Meyers L.A., Becker M.E., Arif M.S., McRaven M.D., Simons L.M., Carias A.M., Martinelli E., Lorenzo-Redondo R., Hultquist J.F., Villinger F.J., Veazey R.S., Hope T.J.An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques.BioRxiv (preprint)2022
Selyutina A., Simons L.M., Kirby K.A., Bulnes-Ramos A., Hu P., Sarafianos S.G., Hultquist J.F., Diaz-Griffero F.TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A ProtectionViruses2022
Simons, L.M, Lorenzo-Redondo R., Gibson M, Kinch S.L., Vandervaart J.P., Reiser N.L., Eren M., Lux E., McNally E.M., Tambur A.R., Vaughan D.E., Bachta K.E.R., Demonbreun A.R., Satchell K.J.F., Achenbach C.J., Ozer E.A., Ison M.G., Hultquist J.F.Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized AdultsOpen Forum Infectious Diseases2022
Lundberg A.L., Lorenzo-Redondo R, Ozer E.A., Hawkins C.A., Hultquist J.F., Welch S.B., Prasad P.V.V., Oehmke J.F., Achenbach C.J., Murphy R.L., White J.I., Havey R.J., Post L.A.Has Omicron Changed the Evolution of the Pandemic? JMIR Public Health Surveillance 2022
Siddiqui S.M., Bowman K.A., Zhu A.L., Fischinger S, Beger S, Maron J.S., Bartsch Y.C., Atyeo C, Gorman M.J., Yanis A, Hultquist J.F. , Lorenzo-Redondo R, Ozer E.A., Simons L.M., Talj R, Rankin D.A., Chapman L, Meade K, Steinhart J, Mullane S, Siebert S, Streeck H, Sabeti P, Halasa N, Musk E.R., Barouch D.H., Menon A.S., Nilles E.J., Lauffenburger D.A., Alter G.Serological Markers of SARS-CoV-2 Reinfection. mBio 2022
Luo Z., Li M., Li T.W., Lv Z., Ye Z., Cisneros W.J., Zhang J., Yuan L., Hultquist J.F., Migueles S.A., Huang L., Zhu J., Jiang W.Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection
mBio. 2022
Ke R, Martinez P.P., Smith R.L., Gibson L.L., Achenbach C.J., McFall S, Qi C, Jacob J, Dembele E, Bundy C, Simons L.M., Ozer E.A., Hultquist J.F., Lorenzo-Redondo R, Opdycke A.K., Hawkins C, Murphy R.L., Mirza A, Conte M, Gallagher N, Luo C.H., Jarrett J, Conte A, Zhou R, Farjo M, Rendon G, Fields C.J., Wang L, Fredrickson R, Baughman M.E., Chiu K.K., Choi H, Scardina K.R., Owens A.N., Broach J, Barton B, Lazar P, Robinson M.L., Mostafa H.H., Manabe Y.C., Pekosz A, McManus D.D., Brooke C.B.Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution OFID (in press). 2022
Martin-Sancho L, Lewinski M.K., Pache L, Stoneham C.A., Yin X, Becker M.E., Pratt D, Churas C, Rosenthal S.B., Liu S, Weston S, De Jesus P.D., O'Neill A.M., Gounder A.P., Nguyen C, Pu Y, Curry H.M., Oom A.L., Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw M.L., Chang M.W., Benner C, Hope T.J., Frieman M.B., García-Sastre A, Ideker T, Hultquist J.F. , Guatelli J, Chanda S.K.Functional landscape
of SARS-CoV-2 cellular restriction
Molecular Cell2021
Lorenzo-Redondo R, Nam H.H., Roberts S.C., Simons L.M., Jennings L.J., Qi C, Achenbach C.J., Hauser A.R., Ison M.G., Hultquist J.F., Ozer E.A.A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways.EBioMedicine2021
Yin X, Riva L, Pu Y, Martin-Sancho L, Kanamune J, Yamamoto Y, Sakai K, Gotoh S, Miorin L, De Jesus P.D., Yang C.C., Herbert K.M., Yoh S, Hultquist J.F., García-Sastre A,
Chanda S.K.
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsCell Reports2021
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor M.J., Haas K.M., Swaney D.L., Nguyen T.T., Mamede J.I., Churas C, Pratt D, Rosenthal S.B., Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus P.D., Moulton H.M., Stein D.A., Chang M.W., Benner C, Ideker T, Albrecht R.A., Hultquist J.F., Krogan N.J., García-Sastre A, Chanda S.K.Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagyNature Microbiology2021
Chai Q, Li S, Collins M.K., Li R, Ahmad I, Johnson S.F., Frabutt D.A., Yang Z, Shen X, Sun L, Hu J, Hultquist J.F., Peterlin B.M., Zheng Y HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivityCell Reports2021
Kociolek L.K., Patel A.B., Hultquist J.F., Ozer E.A., Simons L.M., McHugh M, Muller W.J., Lorenzo-Redondo R Viral whole-genome sequencing to assess impact of universal masking on SARS-CoV-2 transmission among pediatric healthcare workers.Infection Control & Hospital Epidemiology (Epub ahead of print)2021
Selyutina A, Hu P, Miller S, Simons L.M. , Yu H.J., Hultquist J.F., Lee K, KewalRamani V.N., Diaz-Griffero F.GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors. iScience2021
Edward P.R., Reyna M.E., Daly M.K., Hultquist J.F., Muller W.J., Ozer EA, Lorenzo-Redondo R, Seed P.C., Simons L.M., Sheehan K, Staples J, Kociolek Screening Students and Staff for Asymptomatic Coronavirus Disease 2019 in Chicago SchoolsThe Journal of Pediatrics2021
Edward P.R., Lorenzo-Redondo R, Reyna M.E., Simons L.M., Hultquist J.F., Patel A.B., Ozer E.A., Muller W.J., Heald-Sargent T, McHugh M, Dean T.J., Dalal R.M., John J, Manz S.C., Kociolek L.K.Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study medRxiv (preprint) 2021
Hiatt J, Cavero D.A., McGregor M.J., Zheng W, Budzik J.M., Roth T.L., Haas K.M., Wu D, Rathore U, Meyer-Franke A, Bouzidi M.S., Shifrut E, Lee Y, Kumar V.E., Dang E.V., Gordon D.E., Wojcechowskyj J.A., Hultquist J.F., Fontaine K.A., Pillai S.K., Cox J.S., Ernst J.D., Krogan N.J., Marson A Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteinsCell Reports2021
Agarwal D.K., Nandwana V, Henrich S.E., Josyula V.P.V.N., Thaxton C.S., Qi C, Simons L.M., Hultquist J.F., Ozer E.A., Shekhawat G.S., Dravid V.P.. Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platformBiosensors and Bioelectronics2021
Demonbreun A.R., McDade T.W., Pesce L, Vaught L.A., Reiser N.L., Bogdanovic E, Velez M.P., Hsieh R.R., Simons L.M., Saber R, Ryan D.T., Ison M.G., Hultquist J.F., Wilkins J.T., D'Aquila R.T., Mustanski B, McNally E.M.Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposureJCI Insight2021
Lorenzo-Redondo R, Ozer EA, Achenbach CJ, D'Aquila RT, Hultquist J.F.Molecular epidemiology in the HIV and SARS-CoV-2 pandemicsCurrent Opinion in HIV and AIDS2021
Selyutina A., Simons L.M., Bulnes-Ramos A., Hultquist J.F., & Diaz Griffero, F.Restriction of HIV-1 viruses bearing the capsid mutation N74D by human TRIM5a in lymphocytes is due to a loss of Cyclophilin A protection.Cell Reports. 2020
Hiatt J.*, Hultquist J.F.*, Leenay R.T., Rheinemann L., McGregor M.J., Haas P., Roth T.L., Wojcechowskyj J.A., Sperber H., Tobin V., Woo J., Rathore U., Cavero D., Nguyen T.,Pillai S., Sundquist W., May A.P., Marson A., & Krogan N.J. A Functional Map of HIV-Host Interactions in Primary CD4+ T Cells.Nature Immunology. 2020
Selyutina A., Persaud M., Simons L.M., Bulnes-Ramos A., Buffone C., Martinez-Lopez A., Scoca V., Di Nunzio F., Hiatt J., Marson A., Krogan N.J., Hultquist J.F., & Diaz Griffero, F.Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking TRIM5a Binding to the Viral Core.Cell Reports. 30: 3766-3777.2020
Du Y., Hultquist J.F., Zhou Q., Olson A., Tseng Y., Zhang T., Hong M., Tang K., Chen L., Meng X., McGregor M.J., Dai L., Gong D., Martin-Sancho L., Chanda S., Li X., Bensenger S., Krogan N.J., & Sun R. mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1.Nature Communications. 11: 2449. PMID: 32415096.2020
Eckhardt M.*, Hultquist J.F.*, Kaake R., Huttenhain R., & Krogan, N.J. A Systems Approach to Infectious Disease. Nature Reviews Genetics. 21: 339-354. PMID: 32060427.2020
Leenay R.T., Aghazadeh A., Hiatt J., Tse D., Roth T., Apathy R., Shifrut E., Hultquist J.F., Krogan N.J., Wu Z., Cirolia G., Canaj H., Leonetti M.D., Marson A., May A.P., & Zou J.Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells.Nature Biotechnology. 37: 1034-1037. PMID: 31359007.2019
Huttenhain R., Xu J., Burton L.A., Gordon D., Hultquist J.F., Johnson J.R., Satkamp L., Hiatt J., Rhee D.Y, Baek K., Crosby D.C., Frankel A.D., Marson A., Harper J.W., Alpi A.F., Schulman B.A., Gross J.D., & Krogan N.J. ARIH2 is a Vif-dependent Regulator of CUL5-mediated APOBEC3G Degradation in HIV Infection.Cell Host and Microbe. S1931-3128: 30253-30257. PMID: 31253590.2019
Hultquist J.F., Hiatt J., Schumann K., McGregor M.J., Roth T.L., Haas P., Doudna J., Marson A., & Krogan, N.J. CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions.Nature Protocols. 14: 1-27. PMID: 30559373.2019
Batra J.*, Hultquist J.F.*, Liu D., Shtanko O., Von Dollen J., Satkamp L., Jang G.M., Luthra P., Schwarz T.M., Small G.I., Arnett E., Anantpadma M., Reyes A., Leung D.W., Kaake R., Haas P., Schmidt C.B., Schlesinger L.S., LaCount D.J., Davey R.A., Amarasinghe G.K., Basler C.F., & Krogan N.J.Protein interaction mapping identifies RBBP6 as a negative regulator of Ebola virus replication. Cell. 175: 1917-1930. PMID: 30550789.2018
Liu D., Small G., Hultquist J.F., Krogan N.J., Batra J., Basler C., Leung D.W., & Amarasinghe G.K. Biochemical and structural characterization of a host protein that binds Ebola VP30. Journal of Immunology. 200: S182.32.2018
Zhao N., Sebastiano V., Moshkina N., Mena N., Hultquist J.F., Jimenez-Morales D., Ma Y., Rialdi A., Albrecht R., Fenouil R., Sanchez-Aparicio M., Ayllon J., Ravisankar S., Haddad B., Ho J.S.Y., Low D., Jin J., Yurchenko V., Prinja R.K., Tarakhovsky A., Squatrito M., Pinto D., Allette K., Byun M., Smith M.L., Sebra R., Guccione E., Tumpey T., Krogan N.J., Greenbaum B., van Bakel H., Garcia-Sastre A., & Marazzi, I. Influenza virus infection causes global RNAPII termination defects.Nature Structural & Molecular Biology. 25: 885–893. PMID: 30177761.2018
Chen S., Jang G.M., Hüttenhain R., Gordon D.E., Du D., Newton B.W., Johnson J.R., Hiatt J., Hultquist J.F., Johnson T.L., Liu Y., Burton L.A., Ye J., Reichermeier K.M., Stroud R.M., Marson A., Debnath J., Gross J.D., & Krogan N.J. CRL4 AMBRA1 targets ElonginC for ubiquitination and degradation to modulate CRL5 signaling. EMBO. e97508. PMID: 30166453.2018
Dornfield D., Dudek A., Vausselin T., Gunther S., Hultquist J.F., Giese S., Khokhlova-Cubberley D., Chew Y.C., Krogan N.J., Garcia-Sastre A., Schwemmle M., & Shaw M.L. SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Scientific Reports.
8: 2092. PMID: 29391557
2018
Binning J., Smith A., Hultquist J.F., Craik C.S., Caretta N., Campbell M.G., Burton L., La Greca F., McGregor M.J., Ta H.M., Bartholomeeusen K., Peterlin B.M., Krogan N.J., Sevillano N., Cheng Y., & Gross J.D. Fab-based inhibitors reveal ubiquitin independent functions of HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathogens.
14: e1006830. PMID: 29304101.
2018
Rialdi A., Hultquist J.F., Jimenez-Morales D., Peralta Z., Campisi L., Fenouil R., Moshkina N., Wang Z., Laffleur B., Kaake R., McGregor M., Haas K., Pefanis E., Albrecht R.A., Pache L., Chanda S., Jen J., Ochando J., Byun M., Basu U., Garcia-Sastre A., Krogan N.J., van Bakel H., & Marazzi, I. The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity. Cell.
169: 679-692. PMID: 28475896.
2017
Rauch B.J., Silvis M.R., Hultquist J.F., Waters C., McGregor M.J., Krogan N.J., & Bondy-Demony J. Inhibition of CRISPR-Cas9 with Bacteriophage Proteins. Cell.
168: 150-158. PMID: 28041849.
2017
Park R.*, Wang T.*, Koundakjian D., Hultquist J.F., LaMothe-Molina P., Monel B., Schumann K., Yu H., Krupzcak K.M., Garcia-Beltran W., Piechocka-Trocha A., Krogan N.J., Marson A., Sabatini D., Lander E., Hacohen N., & Walker, B.D. A Genome-Wide CRISPR Screen Reveals a Remarkably Restricted Set of HIV Host Dependency Factors. Nature Genetics.
2016 Dec 19. doi: 10.1038/ng.3741. PMID: 27992415.
2016
Hultquist J.F.*, Schumann K.*, Woo J., Manganaro L., Simon V., Doudna J., Krogan N.J., & Marson, A. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Reports.
17: 1438-1452. PMID:
27783955.
2016
Heaton N.S., Moshkina N., Fenouil R., Gardner T.J., Aguirre S., Shah P.S., Zhao N., Manganaro L., Hultquist J.F., Noel J., Sachs D.H., Hamilton J., Leon P.E., Chawdury A., Tripathi S., Melegari C., Campisi L., Hai R., Metreveli G., Gamarnik A.V., García-Sastre A., Greenbaum B., Simon V., Fernandez-Sesma A., Krogan N.J., Mulder L.C., van Bakel H., Tortorella D., Taunton J., Palese P., & Marazzi I. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.Immunity.
44: 46-58. PMID: 26789921.
2016
Kane J.R., Hultquist J.F., Stanley D.J., Binning J.M., Johnson J.R., Johnson T., Newton W., Franks-Skiba K., Harris R.S., Gross J.D., & Krogan, N.J. Lineage-Specific Hijacking of Non-Canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Lentiviral Vif Anti-APOBEC3 Activity. Cell Reports.
11: 1236-1250. PMID: 25981045.
2015
Refsland E.W., Hultquist J.F., Luengas E.M., Ikeda T., Shaban N.M., Law E.K., Brown W.L., Emerman M., & Harris, R.S. Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity. PLoS Genetics.
10: e1004761. PMID: 25411794.
2014
Land A.M., Shaban N.M., Evans L., Hultquist J.F., Albin J.S., & Harris, R.S. APOBEC3F Determinants of HIV-1 Vif Sensitivity. Journal of Virology.
88: 12923-12927. PMID: 25142588.
2014
McDougle, R.M., Hultquist J.F., & Harris, R.S. D316 is Critical for the Enzymatic Activity and HIV-1 Restriction Potential of Human and Rhesus APOBEC3B. Virology.
441: 31-39. PMID: 23542011.
2013
Harris R.S., Hultquist J.F., & Evans D.T. The Restriction Factors of Human Immunodeficiency Virus. J. Biol. Chem.
287: 40875-40883. PMID: 23043100.
2012
Hultquist J.F., McDougle R.M., Anderson B.A., & Harris R.S. HIV Type 1 Viral Infectivity Factor and the RUNX Transcription Factors Interact with Core Binding Factor β on Genetically Distinct Interfaces. ARHR.
28: 1543-1551. PMID: 22725134.
2012
Refsland E.W., Hultquist J.F., & Harris R.S. (2012). Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. PLoS Pathogens.
8: e1002800. PMID: 22807680.
2012
Lackey L., Demorest Z.L., Land A.M., Hultquist J.F., Brown W.L., & Harris R.S. APOBEC3B and AID Have Similar Nuclear Import Mechanisms. J. Mol. Biol.
419: 301-314. PMID: 22446380.
2012
Hultquist J.F., Binka M., LaRue R.S., Simon V., & Harris R.S. Vif Proteins of Human and Simian Immunodeficiency Viruses Require Cellular CBFβ to Degrade APOBEC3 Restriction Factors.Journal of Virology.
86: 2874-2877. PMID: 22205746.
2012
Jäger S.*, Kim D.*, Hultquist J.F.*, Shindo K., LaRue R., Kwon E., Li M., Anderson B., Yen L., Stanley D., Mahon C., Kane J., Franks-Skiba K., Cimermancic P., Burlingame A., Sali A., Craik C., Harris R.S., Gross J., & Krogan N. Vif Hijacks CBFβ to Degrade APOBEC3G and Promote HIV-1 Infection. Nature.
481: 371-375. PMID: 22190037.
2012
Hultquist J.F., Lengyel J.A., LaRue R.S., Lackey L.L., Brown W.L., & Harris R.S. Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity to Restrict Vif-deficient HIV-1. Journal of Virology.
85: 11220-11234.¬ PMID: 21835787.
2011
Albin J.S., Hache G., Hultquist J.F., Brown W.L., & Harris R.S. Long term Restriction by APOBEC3F Selects Human Immunodeficiency Type 1 Variants with Restored Vif Function. Journal of Virology.
84: 10209-10219. PMID: 20686027.
2010
Hultquist J.F. & Harris R.S. Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS. Future Virology.
4: 605-619. PMID: 20174454.
2009
Hultquist J.F. & Dorweiler J.E. Feminized Tassels of Maize mop1 and ts1 Mutants Exhibit Altered Levels of miR156 and Specific SBP-box Genes. Planta.
229: 99-113. PMID: 18800226.
2008