A Systems Approach to Infectious Disease
The Hultquist lab specializes in the development and adaptation of high-throughput, quantitative, systems-based approaches for use in primary models of disease to better understand the host-pathogen relationship.
Pathogens are molecular machines selected over millions of years of co-evolution to exploit the cellular networks of their hosts for optimal replication and survival. This reliance on and manipulation of the host manifests itself in thousands of molecular changes that influence cellular function and may result in disease. A systematic, quantitative understanding of these changes is essential for the understanding of these disease states and for the development of next-generation therapeutics. Only recently, however, have technological advances in molecular measurement and manipulation allowed for the precise, high-throughput determination of mammalian cell architecture.
Leveraging diverse expertise in primary cell models, proteomic profiling, and functional genomics, we work at the intersection of systems biology and infectious disease, defining host-pathogen interactions and their consequences for replication and pathogenesis. Through these efforts, our lab ultimately hopes to strengthen the bridge from big data to targeted discovery to clinical application for the development of personalized, host-driven therapies and the advancement of human health.
Overview
Research Focus Areas
Lab Members
Center for Pathogen Genomics and Microbial Evolution (CPGME)
Emerging and Re-emerging Pathogens Program (EREPP)
POST-DOCTORAL SCHOLAR POSITIONS AVAILABLE
The Hultquist lab is looking to hire talented post-doctoral scholars to lead newly funded projects at the crossroads of primary cell gene editing and HIV molecular virology.
Applicants must: 1) have a doctoral degree in molecular biology, biological sciences, or similar, 2) be comfortable working both independently and as a part of a collaborative team, and 3) have prior wet lab experience in mammalian cell culture and molecular biology. Candidates with previous experience in gene editing, virology, and computational biology are preferred.
The Hultquist lab is located on the downtown medical campus of Northwestern University in Chicago, IL, USA. To apply or inquire about the positions available, please reach out to Dr. Hultquist directly by e-mail at: judd.hultquist@northwestern.edu.