2024
Kim DR, Orr MJ, Yu X, Munshi HH, Wang A, Trudeau C, Kwong AJ, Cheng SY, Scheidt KA. Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma. ACS Med Chem Lett. 2024 Jan 16;15(2):258-264.PMID: 38352843; PMCID: PMC10860193
Begg LR, Orriols AM, Zannikou M, Yeh C, Vadlamani P, Kanojia D, Bolin R, Dunne SF, Balakrishnan S, Camarda R, Roth D, Zielinski-Mozny NA, Yau C, Vassilopoulos A, Huang TH, Kim KA, Horiuchi D. S100A8/A9 predicts response to PIM kinase and PD-1/PD-L1 inhibition in triple-negative breast cancer mouse models. Commun Med (Lond). 2024 Feb 20;4(1):22. PMID: 38378783; PMCID: PMC10879183
2023
Inniss NL, Kozic J, Li F, Rosas-Lemus M, Minasov G, Rybáček J, Zhu Y, Pohl R, Shuvalova L, Rulíšek L, Brunzelle JS, Bednárová L, Štefek M, Kormaník JM, Andris E, Šebestík J, Li ASM, Brown PJ, Schmitz U, Saikatendu K, Chang E, Nencka R, Vedadi M, Satchell KJF. Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. ACS Infect Dis. 2023 Oct 13;9(10):1918-1931. PMID: 37728236.
Campo H, Zha D, Pattarawat P, Colina J, Zhang D, Murphy A, Yoon J, Russo A, Rogers HB, Lee HC, Zhang J, Trotter K, Wagner S, Ingram A, Pavone ME, Dunne SF, Boots CE, Urbanek M, Xiao S, Burdette JE, Woodruff TK, Kim JJ. A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform. Lab Chip. 2023 Nov 7;23(22):4821-4833. PMID: 37846545.
DeWinter MA, Thames AH, Guerrero L, Kightlinger W, Karim AS, Jewett MC. Point-of-Care Peptide Hormone Production Enabled by Cell-Free Protein Synthesis. ACS Synth Biol. 2023 Apr 21;12(4):1216-1226. PMID: 36940255.
Patel AB, Qing J, Tam KH, Zaman S, Luiso M, Radhakrishnan I, He Y. Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nat Commun. 2023 14:3061. PMID: 37244892; PMCID: PMC10224958.
Weerawarna PM, Schiefer IT, Soares P, Fox S, Morimoto RI, Melani RD, Kelleher NL, Luan CH, Silverman RB. Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. ACS Cent Sci. 2023 Dec 20;10(1):87-103. PMID: 38292603; PMCID: PMC10823514.
Wu YL, Lee K, Diloknawarit B, Odom TW. Ligand Separation on Nanoconstructs Affects Targeting Selectivity to Protein Dimers on Cell Membranes. Nano Lett. 2024 Jan 10;24(1):519-524. PMID: 38126338.
Wang J, Waltmann C, Harms C, Hu S, Hegarty J, Shindel B, Wang Q, Dravid V, Shull KR, Torkelson JM, Olvera de la Cruz M. Tailoring Interactions of Random Copolymer Polyelectrolyte Complexes to Remove Nanoplastic Contaminants from Water. Langmuir. 2023 May 30;39(21):7514-7523. PMID: 37196238.
Roberts H, Picca A, Sanson M, Schüller U, Picart T, Ducray F, Green A, Nakano Y, Sturm D, Abdullaev Z, Aldape K. DIPG-26. CLINICAL AND GENOMIC ANALYSIS OF H3K27M-DMG LONG-TERM SURVIVORS REVEALS ENRICHMENT IN MAPK PATHWAY ALTERATIONS. Neuro-Oncology. 2023 Jun 1;25(Supplement_1):i18-9.
Kim DR, Orr MJ, Kwong AJ, Deibler KK, Munshi HH, Bridges CS, Chen TJ, Zhang X, Lacorazza HD, Scheidt KA. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14(5):606-613. PMID: 37197477; PMCID: PMC10184151.
Tsai J, Cejas P, Coppola M, Wang D, Patel S, Wu D, Arounleut P, Wei X, Zhou N, Syamala S, Dubois F. DIPG-20. DELINEATING MEDIATORS OF ONCOGENESIS IN FOXR2-EXPRESSING DIFFUSE MIDLINE GLIOMAS. Neuro-Oncology. 2023 Jun 1;25
2022
Vasan K, Clutter M, Fernandez Dunne S, George MD, Luan CH, Chandel NS, Martínez-Reyes I. Genes Involved in Maintaining Mitochondrial Membrane Potential Upon Electron Transport Chain Disruption. Front Cell Dev Biol. 2022 Feb 16;10:781558. PMID: 35252167; PMCID: PMC8888678.
Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Ramsey KM, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, Macdonald PE, Bass J. P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure. Elife. 2022 Feb 21;11:e75132. PMID: 35188462; PMCID: PMC8860442.
Pincus NB, Rosas-Lemus M, Gatesy SWM, Bertucci HK, Brunzelle JS, Minasov G, Shuvalova LA, Lebrun-Corbin M, Satchell KJF, Ozer EA, Hauser AR, Bachta KER. Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family β-Lactamase from Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2022 Oct 18;66(10):e0098522. PMID: 36129295; PMCID: PMC9578422.
Lee K, Jung I, Odom TW. Delivery Order of Nanoconstructs Affects Intracellular Trafficking by Endosomes. J Am Chem Soc. 2022 Mar 30;144(12):5274-5279. PMID: 35302362; PMCID: PMC9344601.
Rodríguez Y, Unno K, Truica MI, Chalmers ZR, Yoo YA, Vatapalli R, Sagar V, Yu J, Lysy B, Hussain M, Han H, Abdulkadir SA. A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2022 Jun 6;82(11):2110-2123. PMID: 35405009; PMCID: PMC9177667.
Reyes AA, Fishbain S, He Y. Structural and functional analysis of the SET3 histone deacetylase complex. Acta Crystallogr F Struct Biol Commun. 2022 Mar 1;78(Pt 3):113-118. PMID: 35234136; PMCID: PMC8900736.
Stranford DM, Simons LM, Berman KE, Cheng L, Lucks JB, Hultquist JF, Leonard JN. Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells. bioRxiv. 2022 May 14:2022-05.
Evans CE, Peng Y, Zhu MM, Dai Z, Zhang X, Zhao YY. Rabeprazole Promotes Vascular Repair and Resolution of Sepsis-Induced Inflammatory Lung Injury through HIF-1α. Cells. 2022 Apr 22;11(9):1425.
Han Y, Iyamu ID, Clutter MR, Mishra RK, Lyman KA, Zhou C, Michailidis I, Xia MY, Sharma H, Luan CH, Schiltz GE, Chetkovich DM. Discovery of a small-molecule inhibitor of the TRIP8b-HCN interaction with efficacy in neurons. J Biol Chem. 2022 Jul;298(7):102069. PMID: 35623388; PMCID: PMC9243175.
2021
Minasov G, Rosas-Lemus M, Shuvalova L, Inniss NL, Brunzelle JS, Daczkowski CM, Hoover P, Mesecar AD, Satchell KJF. Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2′-O-methyl transfer by SARS-CoV-2 nsp16. Sci Signal. 2021 Jun 29;14(689):eabh2071.PMID: 34131072; PMCID: PMC8432954.
Vincent MP, Karabin NB, Allen SD, Bobbala S, Frey MA, Yi S, Yang Y, Scott EA. The Combination of Morphology and Surface Chemistry Defines the Immunological Identity of Nanocarriers in Human Blood. Adv Ther (Weinh). 2021 Aug;4(4):2100062. PMID: 34485684; PMCID: PMC8411909.
Choo P, Liu T, Odom TW. Nanoparticle Shape Determines Dynamics of Targeting Nanoconstructs on Cell Membranes. J Am Chem Soc. 2021 Mar 31;143(12):4550-4555. PMID: 33735562; PMCID: PMC8075320.
Coughlin EE, Hu J, Lee A, Odom TW. Light-Mediated Directed Placement of Different DNA Sequences on Single Gold Nanoparticles. J Am Chem Soc. 2021 Mar 17;143(10):3671-3676. doi: 10.1021/jacs.0c11699. Epub 2021 Mar 4. PMID: 33661606; PMCID: PMC9210506.
Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D. Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer. Cell Chem Biol. 2022 Mar 17;29(3):358-372.e5. PMID: 34525344; PMCID: PMC8901784.
Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21;13(28):32823-32836. PMID: 34232612; PMCID: PMC9131393.
Lenoir JJ, Parisien JP, Horvath CM. Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation. Cell Rep. 2021 37:110175. PMID: 34965427; PMCID: PMC8787715.
Truica MI, Burns MC, Han H, Abdulkadir SA. Turning Up the Heat on MYC: Progress in Small-Molecule Inhibitors. Cancer Res. 2021 81:248-253. PMID: 33087323; PMCID: PMC7855142.
Kwong AJ, Pham TND, Oelschlager HE, Munshi HG, Scheidt KA. Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett. 2021 Sep 15;12(10):1559-1567.PMID: 34676038; PMCID: PMC8521629.
Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D. Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson’s disease models. JCI insight. 2021 Oct 10;6(19).
Leis J, Luan CH, Audia JE, Dunne SF, Heath CM. Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of herpes simplex virus 1 and 2 and human immunodeficiency virus from cells. Journal of virology. 2021 May 10;95(11):10-128.
Dumrongprechachan V, Soto G, MacDonald ML, Kozorovitskiy Y. Cell type and subcellular compartment specific APEX2 proximity labeling proteomics in the mouse brain. BioRxiv. 2021 Apr 10:2021-04.
Liu SQ, Troy JB, Luan CH, Guillory RJ. Hepatic cell mobilization for protection against ischemic myocardial injury. Scientific reports. 2021 Aug 4;11(1):15830.
Dumrongprechachan V, Salisbury RB, Soto G, Kumar M, MacDonald ML, Kozorovitskiy Y. Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum. Nature communications. 2021 Aug 11;12(1):4855.
2020
Schad EG, Petersen CP. STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling. Curr Biol. 2020 Jan 20;30(2):254-263
Chan CW, Badong D, Rajan R, Mondragón A. Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs. RNA. 2020 Mar;26(3):278-289
Betori RC, Liu Y, Mishra RK, Cohen SB, Kron SJ, Scheidt KA. Targeted Covalent Inhibition of Telomerase. ACS Chem Biol. 2020 Feb 24. doi: 10.1021/acschembio.9b00945. [Epub ahead of print]
2019
Tanaka KJ, Pinkett HW. Oligopeptide-binding protein from nontypeable Haemophilus influenza has ligand-specific sites to accommodate peptides and heme in the binding pocket. J Biol Chem. 2019 Jan 18;294(3):1070-1082.
Deibler KK, Schiltz GE, Clutter MR, Mishra RK, Vagadia PP, O’Connor M, George MD, Gordon R, Fowler G, Bergan R, Scheidt KA. Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors. ChemMedChem. 2019 Mar22;14(6):615-620.
Iyamu ID, Lv W, Malik N, Mishra RK, Schiltz GE. Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands. Bioorg Med Chem. 2019 Mar 16.
Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL. A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer’s-associated pathologies. J Neurochem. 2019 Mar;148(6):822-836.
Paxman JJ, Lo AW, Sullivan MJ, Panjikar S, Kuiper M, Whitten AE, Wang GQ, Luan CH, Moriel DG, Tan LD, Peters KM, Phan MD, Gee CG, Ulett GC, Schembri MA, Heras B. Unique Structural Features of a Bacterial Autotransporter Adhesin Suggest Mechanisms for Interaction with Host Macromolecules. Nature Communications, 2019 March
Cafferty BJ, Ten AS, Fink MJ, Morey S, Preston DJ, Mrksich M, Whitesides GM. Storage of Information Using Small Organic Molecules. ACS Cent Sci. 2019 May 22;5(5):911-916.
Du Z, Valtierra S, Cardona LR, Dunne SF, Luan CH, Li L. Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System. Cell Chem Biol. 2019 Dec 19;26(12):1664-1680
Watkins SM, Ghose D, Blain JM, Grote DL, Luan CH, Clare M, Meganathan R, Horn JR, Hagen TJ. Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126660
Mishra RK, Deibler KK, Clutter MR, Vagadia PP, O’Connor M, Schiltz GE, Bergan R, Scheidt KA. Modeling MEK4 Kinase Inhibitors through Perturbed Electrostatic Potential Charges. J Chem Inf Model. 2019 Oct 28;59(10):4460-4466.
Mishra RK, Clutter MR, Blyth GT, Kosciuczuk EM, Blackburn AZ, Beauchamp EM, Schiltz GE, Platanias LC. Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening. Chem Biol Drug Des. 2019 Oct;94(4):1813-1823
White HV, Brown ST, Bozza TC, Raman IM. Effects of FGF14 and Na(V)β4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons. J GenPhysiol. 2019 Nov 4;151(11):1300-1318
Cichy A, Shah A, Dewan A, Kaye S, Bozza T. Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids. Curr Biol. 2019 Aug 19;29(16):2687-2697
Marcum RD, Radhakrishnan I. Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity. J Biol Chem. 2019 Sep 20;294(38):13928-13938
Fisher OS, Sendzik MR, Ross MO, Lawton TJ, Hoffman BM, Rosenzweig AC. PCu(A)C domains from methane-oxidizing bacteria use a histidine brace to bind copper. J Biol Chem. 2019 Nov 1;294(44):16351-16363
Yu A, Fox SG, Cavallini A, Kerridge C, O’Neill MJ, Wolak J, Bose S, Morimoto RI. Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network. J Biol Chem. 2019 May 10;294(19):7917-7930
2018
Mandhana R, Horvath CM. Sendai Virus Infection Induces Expression of Novel RNAs in Human Cells. Sci Rep. 2018 Nov 14;8(1):16815.
Mandhana R, Qian LK, Horvath CM. Constitutively Active MDA5 Proteins Are Inhibited by Paramyxovirus V Proteins. J Interferon Cytokine Res. 2018 Aug;38(8):319-332.
de Paz AM, Cybulski TR, Marblestone AH, Zamft BM, Church GM, Boyden ES, Kording KP, Tyo KEJ. High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing. Nucleic Acids Res. 2018 Jul 27;46(13)
Phillips JK, Sherman SA, Oungoulian SR, Finan JD. Method for High Speed Stretch Injury of Human Induced Pluripotent Stem Cell-derived Neurons in a 96-well Format. J Vis Exp. 2018 Apr 20;(134).
Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. J Am Chem Soc. 2018 Apr 20.
Aggarwal M, Leser GP, Kors CA, Lamb RA. Structure of the Paramyxovirus Parainfluenza Virus 5 Nucleoprotein in Complex with an Amino-Terminal Peptide of the Phosphoprotein. J Virol. 2018 Feb 12;92(5).
Prasasya RD, Mayo KE. Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells. Endocrinology. 2018 Jan 1;159(1):184-198.
Chan CW, Kiesel BR, Mondragón A. Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding. J Mol Biol. 2018 Apr 4.
Daffern N, Chen Z, Zhang Y, Pick L, Radhakrishnan I. Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket. Biochemistry. 2018 Apr 3;57(13):1977-1986.
Richter CP, Young H, Richter SV, Smith-Bronstein V, Stock SR, Xiao X, Soriano C, Whitlon DS. Fluvastatin protects cochleae from damage by high-level noise. Sci Rep. 2018 Feb 14;8(1):3033.
Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K. Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7408-E7417. doi: 10.1073/pnas.1802021115. Epub 2018 Jul 16. PubMed PMID: 30012602; PubMed Central PMCID: PMC6077698.
Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology. J Clin Invest. 2018 Sep 4. pii: 96209. doi:10.1172/JCI96209. [Epub ahead of print] PubMed PMID: 29990310.
2017
Deibler KK, Mishra RK, Clutter MR, Antanasijevic A, Bergan R, Caffrey M, Scheidt KA. A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family. ACS Chem Biol. 2017 Mar 20. PMID: 28263556
Krist DT, Foote PK, Statsyuk AV. UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis. Curr Protoc Chem Biol. 2017 Mar 2;9(1):11-37. PMID: 28253433
Lyman, K., Han, Y., Heuermann R, Cheng X, Kurz J, Lyman, R, Van Veldhoven P, Chetkovich, D.M. Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. J Biol Chem. 2017 Oct 27;292(43):17718-17730
Nandwana V, Ryoo SR, Kanthala S, McMahon, KM, RinkJS, Li Y, Venkatraman SS, Thaxton CS, and Dravid VP. High-Density Lipoprotein-like Magnetic Nanostructures (HDL-MNS): Theranostic Agents for Cardiovascular Disease. Chem. Mater., 2017, 29 (5), pp 2276–2282
Sood V, Brickner JH. Genetic and Epigenetic Strategies Potentiate Gal4 Activation to Enhance Fitness in Recently Diverged Yeast Species. Curr Biol. 2017 Dec 4;27(23):3591-3602.
Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell. 2017 Oct 1;28(20):2623-2636.
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers. J Neurochem. 2017 Jul 3.
Reed JL, Basu D, Butzler MA, McFall SM. XtracTB Assay, a Mycobacterium tuberculosis molecular screening test with sensitivity approaching culture. Sci Rep. 2017 Jun 16;7(1):3653.
Chetnani B, Mondragón A. Molecular envelope and atomic model of an anti-terminated glyQS T-box regulator in complex with tRNAGly. Nucleic Acids Res. 2017 Jul 27;45(13):8079-8090.
Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Rep. 2017 Nov 7;21(6):1481-1494.
Foote PK, Krist DT, Statsyuk AV. High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor. Curr Protoc Chem Biol. 2017 Sep 14;9(3):174-195.
Park S, Foote PK, Krist DT, Rice SE, Statsyuk AV. UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. J Biol Chem. 2017 Oct 6;292(40):16539-16553
Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK. A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nat Commun. 2017 Mar 28;8:14584.
Strickland M, Ehrlich LS, Watanabe S, Khan M, Strub MP, Luan CH, Powell MD, Leis J, Tjandra N, Carter CA. Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun. 2017 Nov 9;8(1):1391 PMID: 29123089
Yue J, Feliciano TJ, Li W, Lee A, Odom TW. Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs. Bioconjug Chem. 2017 Jun 21;28(6):1791-1800.
2016
Helenius IT, Haake RJ, Kwon YJ, Hu JA, Krupinski T, Casalino-Matsuda SM, Sporn PH, Sznajder JI, Beitel GJ. Identification of Drosophila Zfh2 as a mediator of hypercapnic immune regulation by a genome-wide RNAi screen. J Immunol. 2016 Jan 15;196(2):655-67. PMID: 26643480
Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K., Identification and characterization of PPARα ligands in the hippocampus. Nat Chem Biol. 2016 Oct 17. doi: 10.1038/nchembio.2204
Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF. Structure to function of an α-glucan metabolic pathway that promotes Listeria. Nat Microbiol. 2016 Nov 7;2:16202
Whitlon DS. Drug discovery for hearing loss: Phenotypic screening of chemical compounds on primary cultures of the spiral ganglion. Hear Res. 2016 Aug 2. pii: S0378-5955(16)30255-6.
Nandwana V, Ryoo SR, Kanthala S, De M, Chou SS, Prasad PV, Dravid VP. Engineered Theranostic Magnetic Nanostructures: Role of Composition and Surface Coating on Magnetic Resonance Imaging Contrast and Thermal Activation. ACS Appl Mater Interfaces. 2016 Mar 23;8(11):6953-61.
Zheng J, Chen L, Schwake M, Silverman RB, Krainc D., Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. J Med Chem. 2016 Sep 22;59(18):8508-20.
Han Y, Lyman KA, Clutter M, Schiltz GE, Ismail QA, Cheng X, Luan CH, Chetkovich DM. Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. J Vis Exp. 2016 Nov 11;(117). PMID: 27911380
Helenius IT, Nair A, Bittar HE, Sznajder JI, Sporn PH, Beitel GJ. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen. 2016 Apr;21(4):363-71. PMID: 26701099
Jolly AL, Luan CH, Dusel BE, Dunne SF, Winding M, Dixit VJ, Robins C, Saluk JL, Logan DJ, Carpenter AE, Sharma M, Dean D, Cohen AR, Gelfand VI. A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Cell Rep. 2016 Jan 26;14(3):611-20. PubMed PMID: 26774481.
Light SH, Krishna SN, Minasov G, Anderson WF. An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases. Biochemistry. 2016 Mar1;55(8):1239-45. PubMed PMID:26813771.
Manjasetty BA, Halavaty AS, Luan CH, Osipiuk J, Mulligan R, Kwon K, Anderson WF, Joachimiak A. Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity. J Struct Biol. 2016 Apr;194(1):18-28. PubMed PMID: 26796657.
Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA. The role of Fas-associated phosphatase 1 in leukemia stem cell-persistence during tyrosine kinase inhibitor-treatment of chronic myeloid leukemia. Leukemia. 2016 Mar 17. PubMed PMID:26984787.
Ji Q, Chen PJ, Qin G, Deng X, Hao Z, Wawrzak Z, Yeo WS, Quang JW, Cho H, Luo GZ, Weng X, You Q, Luan CH, Yang X, Bae T, Yu K, Jiang H, He C. Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus. Nat Commun. 2016 Mar 18;7:11000. PubMed PMID: 26987594
Park, S.; Krist, D.T.; Foote, P.; Statsyuk, A.V.; Rice, S., “The quantitative probe UbFluor detects multiple activation mechanisms of the E3 Ubiquitin ligase PARKIN”, submitted.
Krist, D.T.; Park, S.; Boneh, G.; Rice, S.; Statsyuk, A.V., “UbFluor: A Mechanism-Based Probe for HECT E3 Ligases” submitted.
2015
Nussbaum-Krammer CI, Neto MF, Brielmann RM, Pedersen JS, Morimoto RI. Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans. J Vis Exp. 2015 Jan 8;(95):52321. PMID: 25591151
Rotz MW, Culver KS, Parigi G, MacRenaris KW, Luchinat C, Odom TW, Meade TJ. High Relaxivity Gd(III)-DNA Gold Nanostars: Investigation of Shape Effects on Proton Relaxation. ACS Nano. 2015 Mar 24;9(3):3385-96. ACS Nano. 2015 Mar 24;9(3):3385-96.
Tatum MC, Ooi FK, Chikka MR, Chauve L, Martinez-Velazquez LA, Steinbusch HW, Morimoto RI, Prahlad V. Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Curr Biol. 2015 Jan 19;25(2):163-74. PMID: 25557666
Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL. Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers. PLoS One. 2015 Apr 30;10(4):e0125263. PubMed PMID: 25928376.
Tabatadze N, Huang GZ, May RM, Jain A, Woolley CS. Sex difference in molecular signaling at inhibitory synapses in the hippocampus. J Neurosci. 2015 Aug 12;35(32):11252-65. PMID: 26269634
Gógl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetényi C, Reményi A, Weiss EL. The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. PLoS Biol. 2015 May 12;13(5) PMID: 25966461
Whitlon DS, Grover M, Dunne SF, Richter S, Luan CH, Richter CP. Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons. Sci Rep. 2015 Nov 2;5:15960. PubMed PMID: 26521685.
Wang J, Luo C, Shan C, You Q, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J, Jiang H, He C. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79. PubMed PMID: 26587712
Filippova EV, Weigand S, Osipiuk J, Kiryukhina O, Joachimiak A, Anderson WF. Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG. J Mol Biol. 2015 Nov 6;427(22):3538-53
Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM. Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. J Biomol Screen. 2015 Oct;20(9):1124-31. PubMed PMID: 26045196.
Helenius IT, Haake RJ, Kwon YJ, Hu JA, Krupinski T, Casalino-Matsuda SM, Sporn PH, Sznajder JI, Beitel GJ. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. J Immunol. 2015 Dec 7. PubMed PMID: 26643480.
Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 4;22(2):253-65. PubMed PMID: 26118928
Kathman, S. G.; Span, I. Smith, A. T.; Xu, Z.; Zhan, J.; Rosenzweig, A. C.; Statsyuk, A. V. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc. 2015, 137, 12442-12445.
Halavaty AS, Rich RL, Chen C, Joo JC, Minasov G, Dubrovska I, Winsor JR, Myszka DG, Duban M, Shuvalova L, Yakunin AF, Anderson WF. Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1159-75. PMID: 25945581