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Manjasetty BA, Halavaty AS, Luan CH, Osipiuk J, Mulligan R, Kwon K, Anderson WF, Joachimiak A. Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity. J Struct Biol. 2016 Apr;194(1):18-28. PubMed PMID: 26796657.

Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA. The role of Fas-associated phosphatase 1 in leukemia stem cell-persistence during tyrosine kinase inhibitor-treatment of chronic myeloid leukemia. Leukemia. 2016 Mar 17. PubMed PMID:26984787.

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Park, S.; Krist, D.T.; Foote, P.; Statsyuk, A.V.; Rice, S., “The quantitative probe UbFluor detects multiple activation mechanisms of the E3 Ubiquitin ligase PARKIN”, submitted.

Krist, D.T.; Park, S.; Boneh, G.; Rice, S.; Statsyuk, A.V., “UbFluor: A Mechanism-Based Probe for HECT E3 Ligases” submitted.


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Whitlon DS, Grover M, Dunne SF, Richter S, Luan CH, Richter CP. Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons. Sci Rep. 2015 Nov 2;5:15960. PubMed PMID: 26521685.

Wang J, Luo C, Shan C, You Q, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J, Jiang H, He C. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79. PubMed PMID: 26587712

Filippova EV, Weigand S, Osipiuk J, Kiryukhina O, Joachimiak A, Anderson WF. Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG. J Mol Biol. 2015 Nov 6;427(22):3538-53

Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM. Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. J Biomol Screen. 2015 Oct;20(9):1124-31. PubMed PMID: 26045196.

Helenius IT, Haake RJ, Kwon YJ, Hu JA, Krupinski T, Casalino-Matsuda SM, Sporn PH, Sznajder JI, Beitel GJ. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. J Immunol. 2015 Dec 7. PubMed PMID: 26643480.

Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 4;22(2):253-65. PubMed PMID: 26118928

Kathman, S. G.; Span, I. Smith, A. T.; Xu, Z.; Zhan, J.; Rosenzweig, A. C.; Statsyuk, A. V. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc. 2015, 137, 12442-12445.

Halavaty AS, Rich RL, Chen C, Joo JC, Minasov G, Dubrovska I, Winsor JR, Myszka DG, Duban M, Shuvalova L, Yakunin AF, Anderson WF. Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1159-75. PMID: 25945581