The HTAL have purchased and installed a Formulatrix liquid handler with a grant awarded by the Office for Research.   The Mantis features extremely low dead volumes, small footprint, and fast and accurate dispensing for volumes down to 100nL.  At the core of the Mantis is a patented microfluidic valve cluster that measures and dispenses discrete volumes of liquid. Pressure and vacuum open and close each valve on the silicone valve cluster. This chip has two micro-diaphragms (100 nL / 500 nL or 1 µL / 5 µL depending on the chip option) that can fill and dispense as rapidly as 10 times per second. Mantis can automatically dispense up to six reagents, allowing you to dispense complex plates and assay development protocols.

The Chicago Biomedical Consortium (CBC) highlighted Professor William Klein’s recent PLoS One publication in their current news. The CBC is a Chicago based group whose mission is to stimulate collaboration among scientists at Northwestern University, the University of Chicago, and the University of Illinois at Chicago to transform research at the frontiers of biomedicine. The article, Science Spotlight: Synaptic Membrane Nanodiscs May Help Find Alzheimer’s Disease Therapeutics, highlights Professor Klein’s recent publication in the journal, PLoS One. The results provide proof of concept for using SMPL-Nanodiscs in HTS assays for AβO receptors and binding antagonists.