About the Lab

The Lackner lab is interested in the fundamental biological question of how spatial and dynamic organization within cells is achieved. As a model for intracellular organization, we study the mechanisms that position organelles. While once thought to operate independently, it is clear that organelles contact other organelles, and the positioning of organelles and the contacts they make play critical roles in a wide variety of cellular functions. The organelle that has been the primary focus of our research is the mitochondrion. Using a combination of cell biological, genetic, and biochemical approaches, we are addressing fundamental questions about the mechanisms used by cells to position mitochondria as well as form and regulate mitochondrial contacts.

Latest Publications

The multifunctional nature of mitochondrial contact site proteins.

Harper CS, White AJ, Lackner LL. Current Opinion in Cell Biology 2020.

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

Abrisch RG, Gumbin SC, Wisniewski BT, Lackner LL, and Voeltz GK. Journal of Cell Biology 2020.

The Expanding and Unexpected Functions of Mitochondria Contact Sites

Lackner LL. Trends in Cell Biology 2019.

A conserved mechanism for mitochondria-dependent dynein anchoring.

Kraft LM and Lackner LL. Molecular Biology of the Cell 2019.

Direct membrane binding and self-interaction contribute to Mmr1 function in mitochondrial inheritance

Chen W, Ping HA, Lackner LL. Molecular Biology of the Cell 2018.

The role of mitochondria in anchoring dynein to the cell cortex extends beyond clustering the anchor protein.

Schmit HL, Kraft LM, Lee-Smith CF, Lackner LL. Cell Cycle 2018.

Mitochondrial-driven assembly of a cortical anchor for mitochondria and dynein.

Kraft LM and Lackner LL. Journal of Cell Biology 2017.