This perspective paper addresses the stability concerns for electrocatalyst materials used to drive oxidation reactions, particularly considering water oxidation in acidic environments as is relevant for proton exchange membrane water electrolysis technologies. This work compares degradation processes in both diagnostic aqueous media systems and more applied membrane electrode assembly devices and discusses the application of S-number as a metric by which to assess intrinsic material stability in both systems. Finally, we summarize and recommend approaches for standardizing electrocatalyst performance and intrinsic material stability assessments.