Research Objective
Our laboratory’s primary area of investigation centers on understanding the circuit mechanisms that underlie sensory computation. To delve into this realm, we employ the mouse retina as a valuable model system. This choice allows us to precisely stimulate the circuit using its natural input—patterns of light—and capture its natural output, which consists of the spike trains of retinal ganglion cells. To further enhance our research, we leverage the capabilities of genetic manipulations and a wealth of information about different cell types. These resources enable us to unearth novel circuits and unravel their significance in the realm of visual processing. Our research methodologies encompass a range of techniques, including electrophysiology, computational modeling, and circuit tracing through various imaging approaches.
Our laboratory is situated within the Department of Ophthalmology and maintains an affiliation with the NUIN graduate program.
Overview
RGC Types Database
Our goal is to provide a unified typology of mouse RGCs based on measurements of light responses, morphology, and gene expression.
We will also collect information on RGC projection patterns in the brain and species homology.
Browse and download our database of mouse RGC data, updated in real time, and submit your own data to grow the database. Match your data to these types by eye or using our machine learning classifier.
Retinal Computation Book
Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems.