Learn more about the work that we do in the Parvez Lab through our recent publications.

As a Postdoctoral Fellow

(* equal contribution ‡ co-corresponding author)

(22) Nwagbo, U., Parvez, S., Maschek, J. A., and Bernstein, P. S. (2024) Elovl4b Knockout Zebrafish as a Model for Ocular Very-Long-Chain Polyunsaturated Fatty Acid Deficiency. Journal of Lipid Research, 100518

(21) Parvez, S., Zhang, T., and Peterson R. T. (2023) Scalable CRISPR Screens in Zebrafish Using MIC-Drop. Zebrafish: Methods and Protocols, 319-334

(20) Parvez, S., Brandt, Z. J., and Peterson R. T. (2023) Large-scale F0 CRISPR screens in vivo using MIC-Drop. Nature Protocols, 18(6), 1841-1865

(19) Ma, J., Zhang, W., Sun, Z., Parvez, S., Peterson R. T., and Yeh J. R. (2022) Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase. bioRxiv, 2022.10. 30.514454

(18) Parvez, S., Herdman, C., Beerens, M. Chakrabarti, K., Harmer, Z., Yeh, J. J., MacRae, C. A., Yost, H. J., and Peterson, R. T. (2021) MIC-Drop: a platform for large-scale in vivo CRISPR screens. Science, 373(6559), 1146-1151.

(17) Tu, J., Svatunek, D., Parvez, S., Eckvahl, H.,Xu, M., Peterson, R. T., Houk, K., & Franzini, R. M. (2020) Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. Chem. Sci., 11, 169-79.

(16) Tu, J., Svatunek, D., Parvez, S., Liu, A., Levandowski, B., Eckvahl, H., Peterson, R. T., Houk, K., & Franzini, R. (2019). Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles. Angew. Chem., 131(27), 9141–9146.

(15) Tu, J., Xu, M., Parvez, S., Peterson, R. T., & Franzini, R. (2018). Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. JACS, 140(27), 8410–8414

During PhD and Undergraduate

(* equal contribution ‡ co-corresponding author)

(14) Huang, K-T, Ly, P. Poganik, J. R., Parvez, S., Long, M. J. C., and Aye, Y. (2023) Monitoring On-Target Signaling Responses in Larval Zebrafish-Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites. JoVE (Journal of Visualized Experiments), e64846.

(13) van Hall-Beauvais, A., Poganik, J., Huang, K-T., Parvez, S., Zhao, Y., Lin, H-Y., Liu, X., Long, M. J. C.^‡, and Aye, Y.^‡ (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLife, 11, e83373.

(12) Huang, K-T*, Poganik, J.*, Parvez, S., Raja, S., Miller, B., Long, M. J. C., Fetcho, J. R., and Aye, Y. (2023) Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed either Tissue-Specifically or Ubiquitously and Recording the Resultant Functional Electrophile-Induced Redox Responses in Larval Fish. Nature Protocol, 18 (5), 1379-1415.

(11) Poganik, J., Huang, K-T, Parvez, S., Zhao, Y., Raja, S., Long, M. J. C. ^‡, and Aye, Y. ^‡ (2021) Wdr1 and Cofilin are Necessary Mediators of Immune-Cell-Specific Apoptosis Triggered by Tecfidera. Nature Communications, 12(1), 1-15.

(9) Parvez, S.*, Long, M. J. C.*, Poganik, J., & Aye, Y. (2018). Redox Signaling by Reactive Electrophiles and Oxidants. Chem. Rev., 118(18), 8798–8888.

(8) Li, S., Zhang, A., Zatopek, K., Parvez, S., Gardner, A., Corrêa, I., Noren, C., & Xu, M. (2018). Enhancing Multistep DNA Processing by Solid-Phase Enzyme Catalysis on Polyethylene Glycol Coated Beads. Bioconj. Chem., 29(7), 2316–2324.

(7) Long, M. J. C.*, Parvez, S.*, Zhao, Y., Surya, S., Wang, Y., Zhang, S., & Aye, Y. (2017). Akt3 is a privileged first responder in isozyme-specific electrophile response. Nature Chem. Biol., 13(3), 333–338.

(6) Long, M. J. C.*, Lin, H-Y.*, Parvez, S., Zhao, Y., Poganik, J., Huang, P., & Aye, Y. (2017). β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Cell Chem. Biol., 24(8), 944–957.e7.

(5) Parvez, S.*, Long, M. J. C.*, Lin, H-Y., Zhao, Y., Haegele, J., Pham, V., Lee, D., & Aye, Y. (2016). T-REX on-demand redox targeting in live cells. Nature Prot., 11(12), 2328–2356.

(4) Parvez, S.*, Fu, Y.*, Li, J., Long, M. J. C., Lin, H-Y., Lee, D., Hu, G., & Aye, Y. (2015). Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. JACS, 137(1), 10–13.

(3) Fang, X.*, Fu, Y.*, Long, M. J. C., Haegele, J., Ge, E., Parvez, S., & Aye, Y. (2013). Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. JACS, 135(39), 14496–14499.

(2) Fu, Y.*, Long, M.*, Rigney, M., Parvez, S., Blessing, W., & Aye, Y. (2013). Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase. Biochemistry, 52(40), 7050–7059.

(1) Naing, S-H.*, Parvez, S.*, Pender-Cudlip*, M., Groves, J., & Austin, R. (2013). Substrate specificity and reaction mechanism of purified alkane hydroxylase from the hydrocarbonoclastic bacterium Alcanivorax borkumensis (AbAlkB). J. Inorg. Biochem., 121, 46–52