Flanagan Lab

Learn more about the work that we do in the Flanagan laboratory through our recent publications.

View all publications by Dr. Margaret E. Flanagan listed in the National Library of Medicine.

• Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy
  Hopfner F, Tietz AK, Ruf VC,…,Flanagan ME, G, Höglinger G, et al. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Mov Disord. 2022 Aug 23. doi: 10.1002/mds.29164. Epub ahead of print. PMID: 35997131.
• Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
  Nelson PT, Brayne C, Flanagan ME, et. al. Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathol. 2022 Jul;144(1):27-44. doi: 10.1007/s00401-022-02444-1. Epub 2022 Jun 13. PMID: 35697880.
• Deep learning from multiple experts improves identification of amyloid neuropathologies
  Wong DR, Tang Z, Mew NC, Das S, Athey J, McAleese KE, Kofler JK, Flanagan ME, Borys E, White CL 3rd, Butte AJ, Dugger BN, Keiser MJ. Deep learning from multiple experts improves identification of amyloid neuropathologies. Acta Neuropathol Commun. 2022 Apr 28;10(1):66. doi: 10.1186/s40478-022-01365-0. PMID: 35484610; PMCID: PMC9052651.
• Unbiased and robust analysis of co-localization in super-resolution images
  Liu X, Guy CS, Boada-Romero E, Green DR, Flanagan ME, Cheng C, Zhang H. Unbiased and robust analysis of co-localization in super-resolution images. Stat Methods Med Res. 2022 Aug;31(8):1484-1499. doi: 10.1177/09622802221094133. Epub 2022 Apr 21. PMID: 35450486.
• Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups
  Kaivola K, Shah Z, Chia R; International LBD Genomics Consortium, Scholz SW. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain. 2022 Jun 3;145(5):1757-1762. doi: 10.1093/brain/awab402. PMID: 35381062; PMCID: PMC9423712.
• Resolving inflammatory links between myocardial infarction and vascular dementia
  Thorp EB, Flanagan ME, Popko B, DeBerge M. Resolving inflammatory links between myocardial infarction and vascular dementia. Semin Immunol. 2022 Feb 25:101600. doi: 10.1016/j.smim.2022.101600. Epub ahead of print. PMID: 35227567.
• The Frequency of Focal Cortical Dysplasia-Like Histologic Features Near Adult-Type Diffuse Gliomas
  Bitar M, Chornenkyy Y, Flanagan ME, Steffens A, McCortney K, Horbinski C. The Frequency of Focal Cortical Dysplasia-Like Histologic Features Near Adult-Type Diffuse Gliomas. J Neuropathol Exp Neurol. 2022 Jan 21;81(1):48-53. doi: 10.1093/jnen/nlab120. PMID: 35062028; PMCID: PMC8782601.
• Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C
  Kawles A, Nishihira Y, Feldman A, Gill N, Minogue G, Keszycki R, Coventry C, Spencer C, Lilek J, Ajroud K, Coppola G, Rademakers R, Rogalski E, Weintraub S, Zhang H, Flanagan ME, Bigio EH, Mesulam MM, Geula C, Mao Q, Gefen T. Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C. Brain. 2022 Apr 29;145(3):1069-1078. doi: 10.1093/brain/awab368. PMID: 34919645; PMCID: PMC9050539.
• Propagation of TDP-43 proteinopathy in neurodegenerative disorders
  Keszycki R, Jamshidi P, Kawles A, Minogue G, Flanagan ME, Zaccard CR, Mesulam MM, Gefen T, Geula C. Propagation of TDP-43 proteinopathy in neurodegenerative disorders. Neural Regen Res. 2022 Jul;17(7):1498-1500. doi: 10.4103/1673-5374.330609. PMID: 34916432; PMCID: PMC8771119.
• Genome-wide association study and functional validation implicates JADE1 in tauopathy
  Farrell K, Kim S, Han N,…., Flanagan ME, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 Jan;143(1):33-53. doi: 10.1007/s00401-021-02379-z. Epub 2021 Nov 1. PMID: 34719765; PMCID: PMC8786260.
• Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair.
  DeBerge M, Lantz C, Dehn S, Sullivan DP, van der Laan AM, Niessen HWM, Flanagan ME, Brat DJ, Feinstein MJ, Kaushal S, Wilsbacher LD, Thorp EB.J Exp Med. 2021 Sep 6;218(9):e20200667. doi: 10.1084/jem.20200667. Epub 2021 Jul 29.PMID: 34325467
• Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance.
  Geula C, Dunlop SR, Ayala I, Kawles AS, Flanagan ME, Gefen T, Mesulam MM.J Neurochem. 2021 Jul 17. doi: 10.1111/jnc.15471. Online ahead of print.PMID: 34272732 Review.
• Reducing acetylated tau is neuroprotective in brain injury.
  Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF, Seth D, Allen RS, Motz CT, Rao SR, Skelton LA, Pardue MT, Fliesler SJ, Wang C, Tracy TE, Gan L, Liebl DJ, Savarraj JPJ, Torres GL, Ahnstedt H, McCullough LD, Kitagawa RS, Choi HA, Zhang P, Hou Y, Chiang CW, Li L, Ortiz F, Kilgore JA, Williams NS, Whitehair VC, Gefen T, Flanagan ME, Stamler JS, Jain MK, Kraus A, Cheng F, Reynolds JD, Pieper AA.Cell. 2021 May 13;184(10):2715-2732.e23. doi: 10.1016/j.cell.2021.03.032. Epub 2021 Apr 13.PMID: 33852912
• Paucity of Entorhinal Cortex Pathology of the Alzheimer’s Type in SuperAgers with Superior Memory Performance.
  Gefen T, Kawles A, Makowski-Woidan B, Engelmeyer J, Ayala I, Abbassian P, Zhang H, Weintraub S, Flanagan ME, Mao Q, Bigio EH, Rogalski E, Mesulam MM, Geula C.Cereb Cortex. 2021 Jun 10;31(7):3177-3183. doi: 10.1093/cercor/bhaa409.PMID: 33592091
• Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia.
  Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ.Neurology. 2021 Feb 9;96(6):e916-e925. doi: 10.1212/WNL.0000000000011397. Epub 2021 Jan 13.PMID: 33441454
• Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.
  Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF.J Neuropathol Exp Neurol. 2021 Jan 20;80(2):102-111. doi: 10.1093/jnen/nlaa153.PMID: 33367843
• Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease.
  Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X.Sci Adv. 2020 Dec 4;6(49):eabb8680. doi: 10.1126/sciadv.abb8680. Print 2020 Dec.PMID: 33277246
• Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype.
  Buciuc M, Whitwell JL, Kasanuki K, Graff-Radford J, Machulda MM, Duffy JR, Strand EA, Lowe VJ, Graff-Radford NR, Rush BK, Franczak MB, Flanagan ME, Baker MC, Rademakers R, Ross OA, Ghetti BF, Parisi JE, Raghunathan A, Reichard RR, Bigio EH, Dickson DW, Josephs KA.Ann Neurol. 2021 Mar;89(3):520-533. doi: 10.1002/ana.25979. Epub 2020 Dec 17.PMID: 33274526
• Epstein Virus Barr-Positive Diffuse Large B-Cell Lymphoma Associated with Hemophagocytic Lymphohistiocytosis.
  Ricard JA, Charles R, Tommee CG, Yohe S, Bell WR, Flanagan ME.J Neuropathol Exp Neurol. 2020 Aug 1;79(8):915-920. doi: 10.1093/jnen/nlaa061.PMID: 32647871
• Reply: LATE to the PART-y.
  Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murray ME, Nag S, Seeley WW, Sperling RA, White CL, Schneider JA.Brain. 2019 Sep 1;142(9):e48. doi: 10.1093/brain/awz226.PMID: 31359039
• Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.
  Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.Brain. 2019 Jun 1;142(6):1503-1527. doi: 10.1093/brain/awz099.PMID: 31039256
• Concepts for brain aging: resistance, resilience, reserve, and compensation.
  Montine TJ, Cholerton BA, Corrada MM, Edland SD, Flanagan ME, Hemmy LS, Kawas CH, White LR.Alzheimers Res Ther. 2019 Mar 11;11(1):22. doi: 10.1186/s13195-019-0479-y.PMID: 30857563
• TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study.
  Flanagan ME, Cholerton B, Latimer CS, Hemmy LS, Edland SD, Montine KS, White LR, Montine TJ.J Alzheimers Dis. 2018;66(4):1549-1558. doi: 10.3233/JAD-180162.PMID: 30452409
• Localized crystal-storing histiocytosis of the posterior fossa.
  Flanagan ME, Keene CD, Louis DN, Juric-Sekhar G.Neuropathology. 2018 Oct;38(5):529-534. doi: 10.1111/neup.12486. Epub 2018 Jul 31.PMID: 30066398
• Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.
  Flanagan ME, Larson EB, Walker RL, Keene CD, Postupna N, Cholerton B, Sonnen JA, Dublin S, Crane PK, Montine TJ.J Alzheimers Dis. 2018;61(2):653-662. doi: 10.3233/JAD-170414.PMID: 29226863
• Neuropathological Comparison of Adult Onset and Juvenile Huntington’s Disease with Cerebellar Atrophy: A Report of a Father and Son.
  Latimer CS, Flanagan ME, Cimino PJ, Jayadev S, Davis M, Hoffer ZS, Montine TJ, Gonzalez-Cuyar LF, Bird TD, Keene CD.J Huntingtons Dis. 2017;6(4):337-348. doi: 10.3233/JHD-170261.PMID: 29036832
• Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra.
  Turk KW, Flanagan ME, Josephson S, Keene CD, Jayadev S, Bird TD.Cerebellum. 2018 Apr;17(2):143-151. doi: 10.1007/s12311-017-0882-5.PMID: 28887803
• Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer’s disease in an academic clinical practice.
  Bharadwaj R, Cimino PJ, Flanagan ME, Latimer CS, Gonzalez-Cuyar LF, Juric-Sekhar G, Montine TJ, Marshall DA, Keene CD.Histopathology. 2018 Feb;72(3):433-440. doi: 10.1111/his.13345. Epub 2017 Nov 22.PMID: 28815699
• An unusual case of a young patient with Whipple’s disease involving the central nervous system.
  Flanagan ME, Andeen N, Lieberman J, Freeburg J, Williams JR, Hoogestraat DR, Bryan A, Sabath DE.Clin Neuropathol. 2017 Jul/Aug;36(4):199-204. doi: 10.5414/NP301001.PMID: 28502319
• Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.
  Latimer CS, Keene CD, Flanagan ME, Hemmy LS, Lim KO, White LR, Montine KS, Montine TJ.J Neuropathol Exp Neurol. 2017 Jun 1;76(6):458-466. doi: 10.1093/jnen/nlx030.PMID: 28499012
• Clinicopathologic characteristics of metastatic esophageal carcinoma isolated to the pineal region: A case report and review of the literature.
  Flanagan ME, Williams JR, Emerson SN, Chiarelli PA, Ellenbogen RG, Cimino PJ.Exp Mol Pathol. 2017 Apr;102(2):247-250. doi: 10.1016/j.yexmp.2017.02.011. Epub 2017 Feb 16.PMID: 28215583
• Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.
  Flanagan ME, Marshall DA, Shofer JB, Montine KS, Nelson PT, Montine TJ, Keene CD.J Neuropathol Exp Neurol. 2017 Jan 1;76(1):39-43. doi: 10.1093/jnen/nlw104.PMID: 28062571
• Flow-Related Aneurysm within Glioblastoma: A Case Report and Review of Literature.
  Ene CI, Nerva JD, McGrath L, Flanagan ME, Chamberlain MC, Silbergeld DL.World Neurosurg. 2016 May;89:729.e1-6. doi: 10.1016/j.wneu.2016.01.068. Epub 2016 Feb 4.PMID: 26851739