Recent Highlights
Publication List
2022
Martinez Calle M, David V. Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart. Kidney Int. 2022 Aug;102(2):228-230.
PMID: 35870810
Lipocalin-2: a novel link between the injured kidney and the bone. Curr Opin Nephrol Hypertens. 2022 Jul 1;31(4):312-319.
PMCID: PMC9219284
Antagonism between PEDF and TGF-β contributes to type VI osteogenesis imperfecta bone and vascular pathogenesis. J Bone Miner Res. 2022 Mar 8. [Epub ahead of print]
PMID: 35258129
2021
Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease. Kidney Int. 2021 Dec;100(6):1292-1302.
PMCID: PMC8608725
Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease. Bone Res. 2021 Aug 2;9(1):35.
PMCID: PMC8326281
2020
Frazier R, Hodakowski A, Cai X, Lee J, Zakarija A, Stein B, David V, Wolf M, Isakova T, Mehta R. Effects of ferric carboxymaltose on markers of mineral and bone metabolism: A single-center prospective observational study of women with iron deficiency. [published online ahead of print, 2020 Jul 28]. Bone. 2020;141:115559.
Courbon G, Martinez-Calle M, David V. Simultaneous management of disordered phosphate and iron homeostasis to correct fibroblast growth factor 23 and associated outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens. 2020;29(4):359-366.
Martin A, David V. Transcriptomics: a Solution for Renal Osteodystrophy? Curr Osteoporos Rep. 2020 ePub ahead of print.
2019
Francis C, Courbon G, Gerber C, Neuburg S, Wang X, Dussold C, Capella M, Qi L, Isakova T, Mehta R, Martin A, Wolf M, David V. Ferric citrate reduces FGF23 and improves renal and cardiac function in a mouse model of CKD. Kidney Int, 96(6):1346-58. 2019
PMCID: PMC6875640
Genetic Dissection of Femoral and Tibial Microarchitecture. JBMR Plus. 2019 October
Dussold C, Gerber C, White S, Wang X, Qi L, Francis C, Capella M, Courbon G, Liu Y, Li C, Feng JQ, Isakova T, Wolf M, David V, Martin A. DMP1 Prevents Osteocyte Alterations, FGF23 Elevations and Left Ventricular Hypertrophy in Mice with CKD. Bone Research. 7:12. eCollection 2019
PMCID:PMC6483996
2018
Neuburg S, Dussold C, Gerber C, Wang X, Francis C, Qi L, David V, Wolf M, Martin A. Genetic Background Influences Cardiac Phenotype in Murine Chronic Kidney Disease. Nephrol Dial Transplant. 33(7):1129-1137. 2018
PMCID:PMC6030849
2017
Mehta R, Cai X, Hodakowski A, Lee J, Leonard M, Ricardo A, Chen J, Hamm L, Sondheimer J, Dobre M, David V, Yang W, Go A, Kusek JW, Feldman H, Wolf M, Isakova T; CRIC Study Investigators. Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study. Clin J Am Soc Nephrol. 2017;12(11):1795-1803.
PMCID: PMC5672973
Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia. Sci Rep. 2017 Oct 30;7(1):14388
PMCID: PMC5662572
2016
Wysocki J, Ye M, Khattab AM, Fogo A, Martin A, David NV, Kanwar Y, Osborn M, Battlle, D. Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy. Kidney Int, 91(6):1336-46. 2016
PMCID:PMC5429993
David V, Martin A, Isakova T, Zumbrenner-Bullough K, Sun CC, Lin HY, Babitt JL, Wolf M. Inflammation and functional iron deficiency regulate FGF23 production. Kidney Int, 89(1):135-46. 2016
PMCID:PMC4854810
David V, Francis C, Babitt J. Ironing out the crosstalk between FGF23 and inflammation. American Journal of Physiology – Renal Physiology. 312. ajprenal.00359.2016. 10.1152/ajprenal.00359.2016.
Francis C, David V. Inflammation regulates fibroblast growth factor 23 production. Curr Opin Nephrol Hypertens. 2016;25(4):325-332.
PMCID: PMC5016608
David V, Wolf M. Pruning the ricket thicket. J Clin Invest. 2016;126(2):473-476.
PMCID: PMC4731155
2015
Portale AA, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One, 10(11):e0142924. 2015
PMCID:PMC4654537
Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, Li J, Shehadeh LA, Hare JM, David V, Martin A, Fornoni A, Di Marco GS, Kentrup D, Reuter S, Mayer AB, Pavenstädt H, Stypmann J, Kuhn C, Hille S, Frey N, Leifheit-Nestler M, Richter B, Haffner D, Abraham R, Bange J, Sperl B, Ullrich A, Brand M, Wolf M, Faul C. Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. Cell Metab, 22(6):1020-32. 2015
PMCID:PMC4670583
Zhang Y, Huang J, Jiao Y, David V, Kocak M, Roan E, Di’Angelo D, Lu L, Hasty K, Gu W. Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation. ScientificWorldJournal. 2015;2015:728278.
PMCID: PMC4355808
Cho H, Pinkhassik E, David V, Stuart JM, Hasty KA. Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model. Nanomedicine. 2015;11(4):939-946.
2013
David V, Dai B, Martin A, Huang J, Han X, Quarles LD. Calcium Regulates FGF-23 Expression in Bone. Endocrinology, 154(12):4469-82, 2013.
PMCID: PMC3836077
Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci. 2013 Sep 15;126(Pt 18):4085-98.
PMCID: PMC3772385
2012
Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites. Kidney Int. 2012 Nov;82(10):1061-70.
PMCID: PMC3461248
Martin A, David V, Li H, Dai B, Feng JQ, Quarles LD. Overexpression of the DMP1 C-terminal Fragment Stimulates FGF23 and Exacerbates the Hypophosphatemic Rickets Phenotype in Hyp mice. Mol Endocrinol, 26(11):1883-95, 2012.
PMCID: PMC3487625
Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease. PLoS One. 2012;7(9):e46038.
PMCID: PMC3448720
Dai B, David V, Martin A, Huang J, Li H, Jiao Y, Gu W, Quarles LD. A Comparative Transcriptome Analysis Identifying FGF23 Regulated Genes in the Kidney of a Mouse CKD Model. PLoS One, 7(9):e44161, 2012.
PMCID: PMC3435395
Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. J Cell Sci. 2012 Apr 15;125(Pt 8):1945-57.
PMCID: PMC3360919
Martin A, David V, Quarles LD. Regulation and function of the FGF23/Klotho endocrine pathways. Physiol Rev, 92(1):131-55, 2012.
PMCID: PMC3306265
Structure and quantification of microvascularisation within mouse long bones: what and how should we measure?. Bone. 2012 Jan;50(1):390-9.
Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease. J Bone Miner Res. 2012 Jan;27(1):38-46.
PMCID: PMC3439562
2011
Martin A, Liu S, David V, Li H, Feng J, Quarles LD. Bone proteins PHEX and DMP1 Regulate Fibroblastic Growth Factor Fgf23 Expression in Osteocytes through a Common Pathway Involving FGF receptor (FGFR) Signaling. FASEB J, 25(8):2551-62, 2011.
PMCID: PMC3136343
Martin A, Li H, David V, Quarles LD. Compound deletion of FGFR3 and FGFR4 Partially Rescues the Hyp Mouse Phenotype. Am J Physiol Endocrinol Metab, 300(3):E508-17, 2011.
PMCID: PMC3064005
Martin A, David V, Hedge AM, Drezner MK, Rowe PS. ASARM peptides: PHEX-dependent and independent regulation of serum phosphate. Am J Physiol Renal Physiol, 300(3):F783-91, 2011.
PMCID: PMC3064126
FGF23/Klotho : new regulators of Vitamin D metabolism . In: Vitamin D 3rd ed. 3rd ed. Feldman D, Pike WJ, Adams JS, editors. Boston: Academic Press; 2011.
2010
Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis. PLoS One. 2010 Dec 2;5(12):e15240.
PMCID: PMC2996304
ASARM mineralization hypothesis: a bridge too far?. J Bone Miner Res. 2010 Apr;25(4):692-4.
PMCID: PMC3153325
Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation. J Biol Chem. 2010 Jan 8;285(2):1177-87.
PMCID: PMC2801246
MEPE’s diverse effects on mineralization. Calcif Tissue Int. 2010 Jan;86(1):42-6.
PMCID: PMC2810528
2009
Martin A, David V, Hedge AM, Rowe PS. MEPE is a new bone renal hormone and vascularization modulator. Endocrinology, 150(9):4012-23, 2009.
PMCID: PMC2819738
2008
Martin A, David V, Vico L, Thomas T. Impaired energetic metabolism consecutive to central leptin signaling leads to massive appendicular bone loss in hindlimb suspended rats. J Bone Miner Res, 23(12):2040-7, 2008.
Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology, 149(4):1757-72, 2008.
PMCID: PMC2276704
David V, Guignandon A, Martin A, Malaval L, Lafage-Proust MH, Rattner A, Mann V, Noble B, Jones DB, Vico L. Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A, 14(1):117-26, 2008.
2007
Martin A, David V, Malaval L, Lafage-Proust MH, Vico L, Thomas T. Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway. Endocrinology, 148(7):3419-25, 2007.
David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology, 148(5):2553-62, 2007.
Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice. J Anat. 2007 Mar;210(3):259-71.
PMCID: PMC2100282
2006
Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences. Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E440-7.
2005
Martin A, de Vittoris R, David V, Moraes R, Begeot M, Lafage-Proust MH, Alexandre C, Vico L, Thomas T. Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats. Endocrinology, 146(8):3652-9, 2005.
2003
Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography. J Bone Miner Res. 2003 Sep;18(9):1622-31.
2002
High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis. Invest Radiol. 2002 Jan;37(1):40-6.
Our Patents
Martin A, Wolf M, David V. Amelioration of Chronic Kidney Disease. US patent #10377801 issued 08/13/2019
Rowe PSN, Martin A, David V, Forrest L, Moulder KR, Cai S, Aires D. Compounds and Methods for increasing hair growth. US patent #10213479 issued 02/26/2019