2024

Courbon G, David V. Fibroblast growth factor 23 is pumping iron: C-terminal-fibroblast growth factor 23 cleaved peptide and its function in iron metabolism. Curr Opin Nephrol Hypertens. 2024 Jul 1;33(4):368-374.

PMID: 38661434

2023

Courbon G, Kentrup D, Thomas JJ, Wang X, Tsai HH, Spindler J, Von Drasek J, Ndjonko LM, Martinez-Calle M, Lynch S, Hivert L, Wang X, Chang W, Feng JQ, David V, Martin A. FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. JCI Insight. 2023 Dec 22;8(24):e156850.

PMCID: PMC10807721

David V, Salusky IB, Malluche H, Nickolas TL. Renal osteodystrophy: something old, something new, something needed. Curr Opin Nephrol Hypertens. 2023 Nov 1;32(6):559-564.

PMCID: PMC10539012

Martinez-Calle M, Courbon G, Hunt-Tobey B, Francis C, Spindler J, Wang X, Dos Reis LM, Martins CS, Salusky IB, Malluche H, Nickolas TL, Moyses RM, Martin A, David V. Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy. J Clin Invest. 2023 Jun 1;133(11):e159928.

PMCID: PMC10231994

Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Blood. 2023 Jul 6;142(1):106-118.

PMCID: PMC10356820

Lima F, Monier-Faugere MC, Mawad H, David V, Malluche HH. FGF-23 and sclerostin in serum and bone of CKD patients. Clin Nephrol. 2023 May;99(5):209-218. 

PMCID: PMC10286735

2022

Martinez Calle M, David V. Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart. Kidney Int. 2022 Aug;102(2):228-230.

PMID: 35870810

Courbon G, David V. Lipocalin-2: a novel link between the injured kidney and the bone. Curr Opin Nephrol Hypertens. 2022 Jul 1;31(4):312-319.

PMCID: PMC9219284

Kang H, Aryal A C S, Barnes AM, Martin A, David V, Crawford SE, Marini JC. Antagonism between PEDF and TGF-β contributes to type VI osteogenesis imperfecta bone and vascular pathogenesis. J Bone Miner Res. 2022 Mar 8. [Epub ahead of print]

PMID: 35258129

2021

Mehta RC, Cho ME, Cai X, Lee J, Chen J, He J, Flack J, Shafi T, Saraf SL, David V, Feldman HI, Isakova T, Wolf M. Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease. Kidney Int. 2021 Dec;100(6):1292-1302. 

PMCID: PMC8608725

Courbon G, Francis C, Gerber C, Neuburg S, Wang X, Lynch E, Isakova T, Babitt JL, Wolf M, Martin A, David V. Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease. Bone Res. 2021 Aug 2;9(1):35.

PMCID: PMC8326281

2020

Frazier R, Hodakowski A, Cai X, Lee J, Zakarija A, Stein B, David V, Wolf M, Isakova T, Mehta R. Effects of ferric carboxymaltose on markers of mineral and bone metabolism: A single-center prospective observational study of women with iron deficiency. [published online ahead of print, 2020 Jul 28]. Bone. 2020;141:115559.

Courbon G, Martinez-Calle M, David V. Simultaneous management of disordered phosphate and iron homeostasis to correct fibroblast growth factor 23 and associated outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens. 2020;29(4):359-366.

Martin A, David V. Transcriptomics: a Solution for Renal Osteodystrophy? Curr Osteoporos Rep. 2020 ePub ahead of print.

2019

Francis C, Courbon G, Gerber C, Neuburg S, Wang X, Dussold C, Capella M, Qi L, Isakova T, Mehta R, Martin A, Wolf M, David V. Ferric citrate reduces FGF23 and improves renal and cardiac function in a mouse model of CKD. Kidney Int, 96(6):1346-58. 2019
PMCID: PMC6875640

Lu L, Huang J, Xu F, Xiao Z, Wang J, Zhang B, David V, Arends D, Gu W, Ackert-Bicknell C, Sabik O, Farber C, Quarles L, Williams R. Genetic Dissection of Femoral and Tibial Microarchitecture. JBMR Plus. 2019 October

Dussold C, Gerber C, White S, Wang X, Qi L, Francis C, Capella M, Courbon G, Liu Y, Li C, Feng JQ, Isakova T, Wolf M, David V, Martin A. DMP1 Prevents Osteocyte Alterations, FGF23 Elevations and Left Ventricular Hypertrophy in Mice with CKD. Bone Research. 7:12. eCollection 2019
PMCID:PMC6483996 

2018

Neuburg S, Dussold C, Gerber C, Wang X, Francis C, Qi L, David V, Wolf M, Martin A. Genetic Background Influences Cardiac Phenotype in Murine Chronic Kidney Disease. Nephrol Dial Transplant. 33(7):1129-1137. 2018
PMCID:PMC6030849 

2017

Mehta R, Cai X, Hodakowski A, Lee J, Leonard M, Ricardo A, Chen J, Hamm L, Sondheimer J, Dobre M, David V, Yang W, Go A, Kusek JW, Feldman H, Wolf M, Isakova T; CRIC Study Investigators. Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study. Clin J Am Soc Nephrol. 2017;12(11):1795-1803.
PMCID: PMC5672973

Krick S, Baumlin N, Aller SP, Aguiar C, Grabner A, Sailland J, Mendes E, Schmid A, Qi L, David V, Geraghty P, King G, Birket SE, Rowe SM, Faul C, Salathe M. Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia. Sci Rep. 2017 Oct 30;7(1):14388
PMCID: PMC5662572

2016

Wysocki J, Ye M, Khattab AM, Fogo A, Martin A, David NV, Kanwar Y, Osborn M, Battlle, D. Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy. Kidney Int, 91(6):1336-46. 2016
PMCID:PMC5429993 

David V, Martin A, Isakova T, Zumbrenner-Bullough K, Sun CC, Lin HY, Babitt JL, Wolf M. Inflammation and functional iron deficiency regulate FGF23 production. Kidney Int, 89(1):135-46. 2016
PMCID:PMC4854810 

David V, Francis C, Babitt J. Ironing out the crosstalk between FGF23 and inflammation. American Journal of Physiology – Renal Physiology. 312. ajprenal.00359.2016. 10.1152/ajprenal.00359.2016.

Francis C, David V. Inflammation regulates fibroblast growth factor 23 production. Curr Opin Nephrol Hypertens. 2016;25(4):325-332.
PMCID: PMC5016608

David V, Wolf M. Pruning the ricket thicket. J Clin Invest. 2016;126(2):473-476.
PMCID: PMC4731155

2015

Portale AA, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One, 10(11):e0142924. 2015
PMCID:PMC4654537 

Grabner A, Amaral AP, Schramm K, Singh S, Sloan A, Yanucil C, Li J, Shehadeh LA, Hare JM, David V, Martin A, Fornoni A, Di Marco GS, Kentrup D, Reuter S, Mayer AB, Pavenstädt H, Stypmann J, Kuhn C, Hille S, Frey N, Leifheit-Nestler M, Richter B, Haffner D, Abraham R, Bange J, Sperl B, Ullrich A, Brand M, Wolf M, Faul C. Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. Cell Metab, 22(6):1020-32. 2015
PMCID:PMC4670583 

Zhang Y, Huang J, Jiao Y, David V, Kocak M, Roan E, Di’Angelo D, Lu L, Hasty K,  Gu W. Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation. ScientificWorldJournal. 2015;2015:728278.
PMCID: PMC4355808

Cho H, Pinkhassik E, David V, Stuart JM, Hasty KA. Detection of early cartilage damage using targeted nanosomes in a post-traumatic osteoarthritis mouse model. Nanomedicine. 2015;11(4):939-946.

2013

David V, Dai B, Martin A, Huang J, Han X, Quarles LD. Calcium Regulates FGF-23 Expression in Bone. Endocrinology, 154(12):4469-82, 2013.
PMCID: PMC3836077

Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci. 2013 Sep 15;126(Pt 18):4085-98.
PMCID: PMC3772385

2012

Dai B, David V, Alshayeb HM, Showkat A, Gyamlani G, Horst RL, Wall BM, Quarles LD. Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites. Kidney Int. 2012 Nov;82(10):1061-70.
PMCID: PMC3461248

Martin A, David V, Li H, Dai B, Feng JQ, Quarles LD. Overexpression of the DMP1 C-terminal Fragment Stimulates FGF23 and Exacerbates the Hypophosphatemic Rickets Phenotype in Hyp mice. Mol Endocrinol, 26(11):1883-95, 2012.
PMCID: PMC3487625

Qiu N, Xiao Z, Cao L, David V, Quarles LD. Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease. PLoS One. 2012;7(9):e46038.
PMCID: PMC3448720

Dai B, David V, Martin A, Huang J, Li H, Jiao Y, Gu W, Quarles LD. A Comparative Transcriptome Analysis Identifying FGF23 Regulated Genes in the Kidney of a Mouse CKD Model. PLoS One, 7(9):e44161, 2012.
PMCID: PMC3435395

Qiu N, Xiao Z, Cao L, Buechel MM, David V, Roan E, Quarles LD. Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. J Cell Sci. 2012 Apr 15;125(Pt 8):1945-57.
PMCID: PMC3360919

Martin A, David V, Quarles LD. Regulation and function of the FGF23/Klotho endocrine pathways. Physiol Rev, 92(1):131-55, 2012.
PMCID: PMC3306265

Roche B, David V, Vanden-Bossche A, Peyrin F, Malaval L, Vico L, Lafage-Proust MH. Structure and quantification of microvascularisation within mouse long bones: what and how should we measure?. Bone. 2012 Jan;50(1):390-9.

Stubbs JR, He N, Idiculla A, Gillihan R, Liu S, David V, Hong Y, Quarles LD. Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease. J Bone Miner Res. 2012 Jan;27(1):38-46.
PMCID: PMC3439562

2011

Martin A, Liu S, David V, Li H, Feng J, Quarles LD. Bone proteins PHEX and DMP1 Regulate Fibroblastic Growth Factor Fgf23 Expression in Osteocytes through a Common Pathway Involving FGF receptor (FGFR) Signaling. FASEB J, 25(8):2551-62, 2011.
PMCID: PMC3136343

Martin A, Li H, David V, Quarles LD. Compound deletion of FGFR3 and FGFR4 Partially Rescues the Hyp Mouse Phenotype. Am J Physiol Endocrinol Metab, 300(3):E508-17, 2011.
PMCID: PMC3064005

Martin A, David V, Hedge AM, Drezner MK, Rowe PS. ASARM peptides: PHEX-dependent and independent regulation of serum phosphate. Am J Physiol Renal Physiol, 300(3):F783-91, 2011.
PMCID: PMC3064126

David V, Quarles D. FGF23/Klotho : new regulators of Vitamin D metabolism . In: Vitamin D 3rd ed. 3rd ed. Feldman D, Pike WJ, Adams JS, editors. Boston: Academic Press; 2011.

2010

Qiu N, Cao L, David V, Quarles LD, Xiao Z. Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis. PLoS One. 2010 Dec 2;5(12):e15240.
PMCID: PMC2996304

David V, Quarles LD. ASARM mineralization hypothesis: a bridge too far?. J Bone Miner Res. 2010 Apr;25(4):692-4.
PMCID: PMC3153325

Xiao Z, Zhang S, Cao L, Qiu N, David V, Quarles LD. Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation. J Biol Chem. 2010 Jan 8;285(2):1177-87.
PMCID: PMC2801246

Boskey AL, Chiang P, Fermanis A, Brown J, Taleb H, David V, Rowe PS. MEPE’s diverse effects on mineralization. Calcif Tissue Int. 2010 Jan;86(1):42-6.
PMCID: PMC2810528

2009

Martin A, David V, Hedge AM, Rowe PS. MEPE is a new bone renal hormone and vascularization modulator. Endocrinology, 150(9):4012-23, 2009.
PMCID: PMC2819738

2008

Martin A, David V, Vico L, Thomas T. Impaired energetic metabolism consecutive to central leptin signaling leads to massive appendicular bone loss in hindlimb suspended rats. J Bone Miner Res, 23(12):2040-7, 2008.

Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology, 149(4):1757-72, 2008.
PMCID: PMC2276704

David V, Guignandon A, Martin A, Malaval L, Lafage-Proust MH, Rattner A, Mann V, Noble B, Jones DB, Vico L. Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A, 14(1):117-26, 2008.

2007

Martin A, David V, Malaval L, Lafage-Proust MH, Vico L, Thomas T. Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway. Endocrinology, 148(7):3419-25, 2007.

David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology, 148(5):2553-62, 2007.

Gomez C, David V, Peet NM, Vico L, Chenu C, Malaval L, Skerry TM. Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice. J Anat. 2007 Mar;210(3):259-71.
PMCID: PMC2100282

2006

David V, Lafage-Proust MH, Laroche N, Christian A, Ruegsegger P, Vico L. Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences. Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E440-7.

2005

Martin A, de Vittoris R, David V, Moraes R, Begeot M, Lafage-Proust MH, Alexandre C, Vico L, Thomas T. Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats. Endocrinology, 146(8):3652-9, 2005.

2003

David V, Laroche N, Boudignon B, Lafage-Proust MH, Alexandre C, Ruegsegger P, Vico L. Noninvasive in vivo monitoring of bone architecture alterations in hindlimb-unloaded female rats using novel three-dimensional microcomputed tomography. J Bone Miner Res. 2003 Sep;18(9):1622-31.

2002

Barou O, Valentin D, Vico L, Tirode C, Barbier A, Alexandre C, Lafage-Proust MH. High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis. Invest Radiol. 2002 Jan;37(1):40-6.

Martin A, Wolf M, David V. Amelioration of Chronic Kidney Disease. US patent #10377801 issued 08/13/2019

Rowe PSN, Martin A, David V, Forrest L, Moulder KR, Cai S, Aires D. Compounds and Methods for increasing hair growth. US patent #10213479 issued 02/26/2019