We study the mechanisms of chronic kidney disease progression and CKD-associated bone/mineral outcomes. We focus on the regulation and function of the bone secreted hormone FGF23 and its interplay with inflammation and iron metabolism.
About Us
Research
We are interested in defining novel modifiable mechanisms of kidney, bone and cardiovascular diseases.
Environment
The David Lab is located on the downtown Chicago Medical campus in the Division of Nephrology and Hypertension and is also affiliated with the Center for Translational Metabolism (CTMH) and Health and the Feinberg Cardiovascular and Renal Research Institute (FCVRRI).
Training
Our multicultural and diverse team of investigators is actively engaged in training the next generation of scientists at all levels.
Recent Publications
Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease
Simultaneous management of disordered phosphate and iron homeostasis to correct FGF23 and associated outcomes in CKD
Transcriptomics: a Solution for Renal Osteodystrophy?
Ferric citrate reduces FGF23 levels and improves renal and cardiac function in a mouse model of CKD
Sponsors
Our work is generously supported by the National Institutes of Health (NIH) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
We have also received funding from the American Heart Association and from diverse pharmaceuticals companies including Akebia Therapeutics and Vifor.
Principal Investigator
Valentin David, PhD, MSc
Frank Krumlovsky, MD, Professor
Associate Professor of Medicine
Dr. David’s research investigates the causes and consequences of disordered mineral metabolism in chronic kidney disease. The general focus of his lab is the regulation and function of the bone secreted hormone Fibroblast Growth Factor 23 (FGF23) with emphasis on iron metabolism and systemic/local inflammation. He has established multiple national and international collaborations, which includes clinicians to perform bench to bedside science. He is Principal Investigator and co-Investigator on multiple NIH-funded projects, and an active member of the American Society for Bone and Mineral Research and American Society of Nephrology.