Department of Molecular Biosciences
Polyglutamine Repeats in Neurodegenerative Diseases; Function of Molecular Chaperones
We study molecular chaperones and their interactions within mis-folded substrates. Protein mis-folding, as occurs with polyglutamine expansions, is proposed as the causative agent of Huntington’s Disease. Many of our experiments are carried out in the nematode, Caenorhabditis elegans.