Congratulations to Elan for publishing two exciting new papers!
Elan’s TimeCycle method was recently accepted for publication in Bioinformatics. TimeCycle is novel technique for the detection of cycling genes, using a combination of time-delay embedding, nonlinear dimension reduction, persistence homology, and a biologically-informed null model. Curious what those things are? Read the paper or watch the video!
In a separate paper published in Science, Elan describes a secondary analysis of circadian transcriptomic data of skin fibroblasts from mice lacking the core clock gene Bmal1. Using the concordance-based approach pioneered in TimeTrial (previously), we find that Bmal1 is essential for sustaining molecular rhythms.
