Our research on chemical mapping in mouse ES cells is highlighted in Nature Reviews Molecular Cell Biology. Read it here: The chemical brothers: nucleosomes and transcription!
Research highlight
on on on on on on Our research on chemical mapping in mouse ES cells is highlighted in Nature Reviews Molecular Cell Biology. Read it here: The chemical brothers: nucleosomes and transcription!
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I liked to read, But most interesting is “The authors substituted most of the endogenous H4 proteins in mouse embryonic stem (ES) cells with H4S47C. MNase-seq nucleosome maps generated in H4S47C and wild-type ES cells, as well as previously generated maps from different organisms, were generally in agreement. They showed the presence of nucleosome-depleted regions (NDRs) upstream of transcription start sites (TSSs) and at transcription termination sites (TTSs) in actively transcribed genes. SkydivingIndians By contrast, the chemical map revealed generally high nucleosome occupancy spanning the TSS, coding sequence and TTS of actively transcribed genes.”
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