Single Molecule Surface Enhanced Raman Spectroscopy (SM-SERS)

We are interested in understanding the fundamental mechanisms and generality of SMSERS. Resonant dyes, such as Rhodamine 6G, are the most commonly studied molecules because of their large resonance Raman cross-sections. We are striving to achieve reliable and reproducible single molecule (SM) detection of non-resonant molecules to further expand the applicability of SMSERS. Previous work in our group has focused on establishing a reliable proof of SMSERS and understanding the excitation wavelength dependence of the SMSERS signal intensity. We have recently proven SM detection with discrete triangular nanopyramids prepared via nanosphere lithography and are currently exploring non-resonant detection with these nanoparticles. Additionally, we have recently identified a new family of chromophores, the triphenylmethanes, as SMSERS active and have conducted correlated experiments to relate a SMSERS active junction to its detailed morphology and dark-field LSPR scattering spectra.

Nolan Wong, 5th year graduate student
Emma Vander Ende, 4th year graduate student

Recent Publications:

“Single Molecule Surface-Enhanced Raman Spectroscopy without Nanogaps,” Alyssa B. Zrimsek, Anne-Isabelle Henry, and Richard P. Van Duyne, J. Phys. Chem. Lett., 4, 3206−3210 (2013).

“Single-Molecule Surface-Enhanced Raman Spectroscopy of Crystal Violet Isotopologues: Theory and Experiment,” S. L. Kleinman, E. Ringe, N. Valley, K. L. Wustholz, E. Phillips, K. A. Scheidt, G. C. Schatz, and R. P. Van Duyne, J. Am. Chem.Soc., 133, 4115-4122 (2011)

“Exploring single-molecule SERS and single-nanoparticle plasmon microscopy,” K.L. Wustholz, A-I. Henry, J. M. Bingham, S. L. Kleinman, R. G. Freeman, M. J. Natan, R. P. Van Duyne, Proceesings of SPIE-The International Society for Optical Engineering, 7394-739403 (2009)

“Surface-Enhanced Raman Excitation Spectroscopy of a Single Rhodamine 6G Molecule,” J. A. Dieringer, K. L. Wustholz, D. J. Masiello, J. P. Camden, S. L. Kleinman, G. C. Schatz, R. P Van Duyne, J. Am. Chem. Soc., 131, 849-854 (2009).

“A Frequency Domain Existence Proof of Single-Molecule Surface-Enhanced Raman Spectroscopy,” J. A. Dieringer, R. B. Lettan II, K. A. Scheidt, and R. P. Van Duyne., J. Am. Chem. Soc., 129, 16249-16256 (2007).

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  • Professor Richard Van Duyne

    Additional Information

    Discoverer of Surface-enhanced Raman Spectroscopy (1977)
    Inventor of Nanosphere Lithography (1995) & Localized Surface Plasmon Resonance Spectroscopy (2000)

  • Group Members

    Professor Van Duyne has, in his career to date, advised a total of 87 graduate students and 47 postdoctoral fellows. Every year, Professor Van Duyne gives a talk to introduce new graduate students to our research. The 2017 seminar slides are available here.

  • News

    Professor Van Duyne was recently named a Vannevar Bush Faculty Fellow by the U.S. Department of Defense to conduct "high risk, high payoff" basic scientific research. Read more here