In Vivo Metabolites Sensing

Our work involves developing an optical sensing platform which utilizes metal nanostructures and surface-enhanced Raman spectroscopy (SERS) for sensitive and selective detection of glucose. People with diabetes face the daily challenge of maintaining euglycemia. Continuous glucose monitoring (CGM) has improved the outlook for those suffering from diabetes. Currently, we progress toward to an implantable surface-enhanced spatially offset Raman spectroscopy (SESORS) based glucose sensor for continuous, in vivo, transcutaneous glucose detection.  Good and consistent predictive values were obtained with our sensor, with relatively low error. Remarkably, the error for low glucose concentration (< 80 mg/dL) exceeds the current International Organization Standard (ISO/DIS 15197) requirements. No commercially available glucose sensing techniques achieve enough accuracy during hypoglycemic episodes. The sensor demonstrated functionality for 17 days after implantation, including 12 days under the laser safety level for human skin exposure with only one calibration. The SESORS based sensor shows promise for reliable continuous glucose sensing for optimal glycemic control. Looking to the future, evaluation of the performance of the sensor over a long period will be the short term goal. In the long run, biocompatible surface coatings will be integrated by encapsulation of the entire SERS substrate to improve the sensor’s biocompatibility and increase its lifetime. Furthermore, we are developing new partition layers to expand the biological targets accessible to in vivo SERS from glucose to those included in the Chem 7 panel and others. We believe that our SESORS sensor approach will have important applications in new areas of fundamental research as well as treatment and care of diabetic and ICU patients.

Emma Vander Ende, 4th year graduate student
Ji Eun Park, 3rd year graduate student

Recent Publications:

Ma, K., J.M. Yuen, et al. (2011). “In Vivo, Transcutaneous Glucose Sensing Using Surface-Enhanced Spatially Offset Raman Spectroscopy: Multiple Rats, Improved Hypoglycemic Accuracy, Low Incident Power, and Continuous Monitoring for Greater Than 17 Days.” Analytical Chemistry Submitted.

Yuen, J. M., N. C. Shah, et al. (2010). “Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model.” Analytical Chemistry 82(20): 8382-8385.

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  • Professor Richard Van Duyne

    Additional Information

    Discoverer of Surface-enhanced Raman Spectroscopy (1977)
    Inventor of Nanosphere Lithography (1995) & Localized Surface Plasmon Resonance Spectroscopy (2000)

  • Group Members

    Professor Van Duyne has, in his career to date, advised a total of 87 graduate students and 47 postdoctoral fellows. Every year, Professor Van Duyne gives a talk to introduce new graduate students to our research. The 2017 seminar slides are available here.

  • News

    Professor Van Duyne was recently named a Vannevar Bush Faculty Fellow by the U.S. Department of Defense to conduct "high risk, high payoff" basic scientific research. Read more here