Welcome to the Tambur Laboratory

at Northwestern University

WHAT WE DO

Our Research

Our research focuses on understanding the immunogenicity of HLA-DQ antigens and it’s role in antibody-mediated rejection in solid organ transplantation. Increasing evidence has demonstrated that DQ mismatches between transplant recipient and donor are the most common to induce de novo donor-specific antibodies (DSA). HLA-DQ antibodies are likely also the most detrimental to graft survival. Understanding the unique structural and molecular properties that make the HLA-DQ molecule so pathogenic may eventually help us better predict which mismatches will induce harmful antibody formation, and which are more permissible. This information will promote better informed clinical decisions.

Histocompatibility

As an ASHI-accredited clinical laboratory part of the Comprehensive Transplant Center at Northwestern University, we perform a variety of high-complexity testing relating to HLA typing, antibody testing, histocompatibility, and engraftment monitoring of solid organ and stem cell transplants. Working closely with the clinicians in the Department of Surgery, we also provide consultations regarding the interpretations of our laboratory assays supporting outstanding, comprehensive care to our patients.

Biorepository

In order to aid investigators or clinicians in future scientific studies, we maintain an extensive biorepository consisting of well-characterized and well-preserved biospecimens from solid organ and stem cell transplant patients, including serum, plasma, whole blood, white blood cells, and urine.

LAB NEWS

Announcing Our Latest Collaboration with Pure Protein

We are excited to be partnering with Dr. Rico Buchli of Pure Transplant Solutions and to utilize their extensive library of soluble HLA proteins in order to better understand the immunogenicity of HLA-DQ antigens and its role in antibody-mediated rejection

Measuring human leukocyte antigen alloantibodies: beyond a binary decision

Newly published in Current Opinion in Organ Transplantation

Our work was presented the ATC first day plenary symposium !!!

     

We are located in the Tarry Building, on Northwestern University’s Chicago campus

Research

Learn about the research we do 

People

Meet all the members of our lab

Publications

Read the most recent publications from the Tambur lab

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