Publications

Full publication list on Google Scholar 

 

Main Publications

1. Schoof M*, Faust B*, Saunders RA*, Sangwan S*, Rezelj V*, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M; QCRG Structural Biology Consortium, Walter P, Manglik A. “An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation.” Science (2020), doi 10.1126/science.abe3255. *equal contribution
2. Sangwan S*, Sahay S*, Murray K, Morgan S, Guenther E, Jiang L, Williams C, Vinters H, Goedert M and Eisenberg D “Inhibition of synucleinopathic seeding by rational designed inhibitors.” eLife (2020), doi: 10.7554/eLife.46775.
3. Sangwan S, Sawaya M, Murray K, Hughes M, Eisenberg D “Atomic structures of corkscrew-forming segments of SOD1 suggest molecular differences between toxic and non-toxic amyloid oligomers.” Protein Science (2018), doi: 10.1002/pro.3391. Cover Article
4. Sangwan S, Zhao A, Adams K, Jayson C, Sawaya M, Guenther E, Soriaga A, Pan A, Ngo J, Moore D, Do T, Goldschmidt L, Nelson R, Bowers M, Koehler C, Shaw D, Novitch B, Eisenberg D “Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis.” Pro Natl. Acad Sci (2017), doi: 10.1073/pnas.1705091114.
5. Sangwan S, Eisenberg D ‘Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis’ Review Postepi Biochemii (2016)
6. Do D*, LaPointe N*, Sangwan*, Teplow D, Feinstein S, Sawaya M, Eisenberg D, and Bowers M. “Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants.” The Journal of Physical Chemistry B (2014), doi:10.1021/jp502473s. *equal contribution

 

Other Publications

1. Lawrence R, Shoemaker S, Deal A, Sangwan S, Anand A, Wang L, Marqusee S, Walter P “A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.” Nat Chem Biol (2024),  doi: 10.1038/s41589-023-01453-9.
2. Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido E, Kwok S, Chalkley R, Li K, Krogan N, Swaney D, Burlingame A, Floor S, Sil A, Walter P, Mukherjee S. “A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.” Nat Cell Biol (2023), doi: 10.1038/s41556-023-01248-z.
3. Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O’Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D; QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL; Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. Science (2020), doi: 10.1126/science.abe9403.
4. Do T, Sangwan S, de Almeida N, Ilitchev A, Giammona M, Sawaya M, Buratto S, Eisenberg D, Bowers M. Distal amyloid β-protein fragments template amyloid assembly. Protein Sci (2018), doi: 10.1002/pro.3375.
5. Soriaga A, Sangwan S, Macdonald R, Sawaya M, Eisenberg D “Crystal structures of IAPP amyloidogenic segments reveal a novel packing motif of out-of-register beta sheets.” The Journal of Physical Chemistry B (2016), doi: 10.1021/acs.jpcb.5b09981.
6. Rodriguez J, Ivanova M, Sawaya M, Cascio D, Reyes F, Shi D, Sangwan S, Guenther E, Johnson L, Zhang M, Jiang L, Arbing M, Nannenga B, Hattne J, Whitelegge J, Brewster A, Messerschmidt M, Boutet S, Sauter N, Gonen T, Eisenberg D “Structure of the toxic core of α-synuclein from invisible crystals.” Nature (2015), doi:10.1038/nature15368