Annotated High-yield and Landmark Articles

Page under construction

Critical Care Medicine

ARDS

 

Cardiovascular

Atrial Fibrillation in the ICU – CHEST, 2018

  • Helpful overview of a common ICU problem. Figure 1 reviews pathobiology of new-onset atrial fib in ICU. Figure 2 proposes a step-wise approach to management

 

ECMO

Veno-Arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock: An Introduction for the Busy Clinician – CHEST 2019 

  • Readable summary of VA ECMO including a nice overview of the LV venting and north-south syndrome

Mechanical Ventilation

Patient-ventilator interactions. Implications for clinical management – AJRCCM, 2013

  • Evergreen review of trigger, flow, and cycle dyssynchronies including recognition and management

Sepsis

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL Trial) – NEJM, 2018

  • Landmark study of hydrocortisone 200mg daily by continuous infusion vs placebo in 3,658 mechanically ventilated patients with septic shock (defined as use of vasopressor for at least 4 hrs). No difference in 90-day mortality between groups, but patients in the intervention arm with faster shock resolution, shorter time to liberation from mechanical ventilation, and shorter time to ICU discharge. Importantly, there was no increase in bacteremia or fungemia in the steroid arm. Steroids were continued for 7 days or until ICU discharge.

Pulmonary

Asthma

COPD

Cystic lung disease

Concise Clinical Review of Diffuse Cystic Lung Disease Part 1 and Part 2 –  AJRCCM 2015

  • High-yield review of cystic lung disease including LAM, PLCH, Birt-Hogg-Dube, LIP, and amyloid (see Infographics for helpful summary table)

 Imaging

Pictorial essay: multinodular disease: a high-resolution CT scan diagnostic algorithm – CHEST 2006

  • Helpful review of secondary pulmonary lobule anatomy, how to describe nodule distribution, and using distribution to inform differential diagnosis

 

Interstitial Lung Disease

 

Pulmonary complications of non-pulmonary disease

An update on pulmonary complications of hematopoietic stem cell transplantation – CHEST 2013

  • Nice review of both infectious and non-infectious complications. Figure 1 provides a helpful review of complications by timing relative to transplant. Table 1 compares peri-engraftment respiratory distress syndrome, idiopathic pneumonia syndrome, and DAH