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Inhalation Toxicology Research Institute Data



ITRI

HISTORY

ITRI conducted dog life-span experiments on a variety of fission products including 90Sr – 90Y, 91Y, 95Zr – 95Nb, 106Ru -106Rh, 131I, 137Cs -137mBa, 140Ba -140La, and 144Ce -144Pr, radionuclides that predominate in a reactor inventory after a period of sustained operation. Subsequently, investigations were extended to include plutonium and transplutonium elements associated with breeder reactors. Long term rodent studies at ITRI include repeated inhalation exposures of 239Pu or 144Ce oxide , cigarette smoke, and 4) injected chemical carcinogens. Additional long-term studies have involved inhaled 244Cm oxide, injected Thorotrast and 239Pu citrate.

Investigators associated with the ITRI radiobiology studies were (in alphabetic order): B.B. Boecker, R.G. Cuddihy, J.H. Diel, S.A. Felicetti, N.A. Gillett, W.C. Griffith, R.A. Guilmette, F.F. Hahn, C.H. Hobbs, D.L. Lundgren, J.L. Mauderly, R.O. McClellan, J.A. Mewhinney, B.A. Muggenburg, R.C. Pfleger, J.A. Pickrell, O.G. Raabe, H.C. Redman, B.R. Scott, D.O. Slauson, M.B. Snipes, R.G. Thomas, R.C. Thompson.

The information provided here was compiled and created by the staff of the NRA, with additions made by Lori Snyder of the Woloschak lab in 2022.

For more information, see fact sheet:
https://www.energy.gov/sites/default/files/2021-08/ITLFactSheet.pdf

Full Bibliography of ITRI Publications

Full Bibliography of ITRI Publications

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Medical Data

ITRI Radiobiology Medical Files

Access Restricted – Password Required

Medical Data

Annual Report Studies Data

To see full study and dose measurements, see Study Exposure Measurement report

238-PUO2 Single Exposure

238 PUO2 Monodisperse Aerosol (3.0 AMAD), Longevity Study

238 PUO2 Monodisperse Aerosol (1.5 AMAD), Longevity Study

239-PUO2 Single Exposure

239PUO2 MONODISPERSE AEROSOL (0.75 AMAD), LONGEVITY STUDY.pdf

239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), IMMATURE LONGEVITY STUDY.pdf

239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), LONGEVITY STUDY.pdf

239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), AGED LONGEVITY STUDY.pdf

239PUO2 MONODISPERSE AEROSOL (3.0 AMAD), LONGEVITY STUDY.pdf

Insoluble Beta Emitters

144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE LONGEVITY STUDY.pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE LONGEVITY STUDY.pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, AGED LONGEVITY STUDY.pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY (SERIES I).pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY (SERIES II).pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, SACRIFICE STUDY.pdf

144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE SACRIFICE STUDY.pdf

90SR IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf

90Y IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf

91Y IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf

Insoluble Ce repeated

144CE IN FUSED ALUMINOSILICATE PARTICLES, REPEATED EXPOSURE STUDY.pdf

Soluble Ce & Y

91YCL3, LONGEVITY STUDY.pdf

91YCL3, SACRIFICE STUDY.pdf

144CECL3, LONGEVITY STUDY.pdf

Soluble Cs

137CSCL, LONGEVITY STUDY.pdf

Soluble Sr

90SRCL2, LONGEVITY STUDY.pdf

90SRCL2, SACRIFICE STUDY.pdf

Frequently Asked Questions

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