Contents
HISTORY
ITRI conducted dog life-span experiments on a variety of fission products including 90Sr – 90Y, 91Y, 95Zr – 95Nb, 106Ru -106Rh, 131I, 137Cs -137mBa, 140Ba -140La, and 144Ce -144Pr, radionuclides that predominate in a reactor inventory after a period of sustained operation. Subsequently, investigations were extended to include plutonium and transplutonium elements associated with breeder reactors. Long term rodent studies at ITRI include repeated inhalation exposures of 239Pu or 144Ce oxide , cigarette smoke, and 4) injected chemical carcinogens. Additional long-term studies have involved inhaled 244Cm oxide, injected Thorotrast and 239Pu citrate.
Investigators associated with the ITRI radiobiology studies were (in alphabetic order): B.B. Boecker, R.G. Cuddihy, J.H. Diel, S.A. Felicetti, N.A. Gillett, W.C. Griffith, R.A. Guilmette, F.F. Hahn, C.H. Hobbs, D.L. Lundgren, J.L. Mauderly, R.O. McClellan, J.A. Mewhinney, B.A. Muggenburg, R.C. Pfleger, J.A. Pickrell, O.G. Raabe, H.C. Redman, B.R. Scott, D.O. Slauson, M.B. Snipes, R.G. Thomas, R.C. Thompson.
The information provided here was compiled and created by the staff of the NRA, with additions made by Lori Snyder of the Woloschak lab in 2022.
For more information, see fact sheet:
https://www.energy.gov/sites/default/files/2021-08/ITLFactSheet.pdf
Annual Reports 1962 - 1996
Full Bibliography of ITRI Publications
ITRI Radiobiology Medical Files
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Annual Report Studies Data
To see full study and dose measurements, see Study Exposure Measurement report
238-PUO2 Single Exposure
238 PUO2 Monodisperse Aerosol (3.0 AMAD), Longevity Study
238 PUO2 Monodisperse Aerosol (1.5 AMAD), Longevity Study
239-PUO2 Single Exposure
239PUO2 MONODISPERSE AEROSOL (0.75 AMAD), LONGEVITY STUDY.pdf
239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), IMMATURE LONGEVITY STUDY.pdf
239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), LONGEVITY STUDY.pdf
239PUO2 MONODISPERSE AEROSOL (1.5 AMAD), AGED LONGEVITY STUDY.pdf
239PUO2 MONODISPERSE AEROSOL (3.0 AMAD), LONGEVITY STUDY.pdf
Insoluble Beta Emitters
144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE LONGEVITY STUDY.pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE LONGEVITY STUDY.pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, AGED LONGEVITY STUDY.pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY (SERIES I).pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY (SERIES II).pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, SACRIFICE STUDY.pdf
144CE IN FUSED ALUMINOSILICATE PARTICLES, IMMATURE SACRIFICE STUDY.pdf
90SR IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf
90Y IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf
91Y IN FUSED ALUMINOSILICATE PARTICLES, LONGEVITY STUDY.pdf
Insoluble Ce repeated
144CE IN FUSED ALUMINOSILICATE PARTICLES, REPEATED EXPOSURE STUDY.pdf
Soluble Ce & Y
Soluble Cs
Soluble Sr
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