BONUS QUESTION: Why is it called Fetroja?
This unique cephalosporin antibiotic utilizes Fe-siderophores to gain access to the cell. Access is between the inner and outer membrane. This explains the weak activity against Gram Positive bacteria (as well as anaerobes). This agent has good in vitro activity against Enterobacteraciae (ESBL and CRE), Pseudomonas, Acinetobacter and Stenotrophomonas.
How cefiderocol works:
The data where presented to the FDA and the agent was approved for complicated UTI. Continue reading