[2024]
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z. RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes. Nat Commun. 2024 Sep 29;15(1):8434. doi: 10.1038/s41467-024-52723-6. PubMed PMID: 39343966; PubMed Central PMCID: PMC11439917.
Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, Davis DA, Sun X, Zhang B, Yue Z. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease. Sci Adv. 2024 Jan 12;10(2):eadi8287. doi: 10.1126/sciadv.adi8287. Epub 2024 Jan 10. PubMed PMID: 38198537; PubMed Central PMCID: PMC10780895.
[2023]
Choi I, Wang M, Yoo S, Xu P, Seegobin SP, Li X, Han X, Wang Q, Peng J, Zhang B, Yue Z. Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. Nat Cell Biol. 2023 Jul;25(7):963-974. doi: 10.1038/s41556-023-01158-0. Epub 2023 May 25. PubMed PMID: 37231161; PubMed Central PMCID: PMC10950302.
[2022]
Choi I, Heaton GR, Lee YK, Yue Z. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Sci Adv. 2022 Oct 28;8(43):eabn1298. doi: 10.1126/sciadv.abn1298. Epub 2022 Oct 26. Review. PubMed PMID: 36288297; PubMed Central PMCID: PMC9604594.
[2021]
Deng Z, Li X, Blanca Ramirez M, Purtell K, Choi I, Lu JH, Yu Q, Yue Z. Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14). doi: 10.1073/pnas.2020215118. PubMed PMID: 33785595; PubMed Central PMCID: PMC8040602.
[2020]
Choi I, Seegobin SP, Liang D, Yue Z. Synucleinphagy: a microglial “community cleanup program” for neuroprotection. Autophagy. 2020 Sep;16(9):1718-1720. doi: 10.1080/15548627.2020.1774149. Epub 2020 Jun 9. PubMed PMID: 32453651; PubMed Central PMCID: PMC8386613.
Pan PY, Sheehan P, Wang Q, Zhu X, Zhang Y, Choi I, Li X, Saenz J, Zhu J, Wang J, El Gaamouch F, Zhu L, Cai D, Yue Z. Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice. Hum Mol Genet. 2020 Aug 11;29(14):2300-2312. doi: 10.1093/hmg/ddaa080. PubMed PMID: 32356558; PubMed Central PMCID: PMC7424763.
Yang H, An J, Choi I, Lee K, Park SM, Jou I, Joe EH. Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum. Mol Brain. 2020 Jul 22;13(1):103. doi: 10.1186/s13041-020-00642-0. PubMed PMID: 32698847; PubMed Central PMCID: PMC7374828.
Seegobin SP, Heaton GR, Liang D, Choi I, Blanca Ramirez M, Tang B, Yue Z. Progress in LRRK2-Associated Parkinson’s Disease Animal Models. Front Neurosci. 2020;14:674. doi: 10.3389/fnins.2020.00674. eCollection 2020. Review. PubMed PMID: 32765209; PubMed Central PMCID: PMC7381130.
Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020 Mar 13;11(1):1386. doi: 10.1038/s41467-020-15119-w. PubMed PMID: 32170061; PubMed Central PMCID: PMC7069981.
[2019]
Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4. PubMed PMID: 31775806; PubMed Central PMCID: PMC6882183.
Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z, Zhang B. The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease. Nat Commun. 2019 Nov 20;10(1):5234. doi: 10.1038/s41467-019-13144-y. PubMed PMID: 31748532; PubMed Central PMCID: PMC6868244.
[2016]
Choi I, Byun JW, Park SM, Jou I, Joe EH. LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2. Exp Neurobiol. 2016 Oct;25(5):269-276. doi: 10.5607/en.2016.25.5.269. Epub 2016 Oct 26. PubMed PMID: 27790061; PubMed Central PMCID: PMC5081473.
Park S, Han S, Choi I, Kim B, Park SP, Joe EH, Suh YH. Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS One. 2016;11(9):e0163029. doi: 10.1371/journal.pone.0163029. eCollection 2016. PubMed PMID: 27631370; PubMed Central PMCID: PMC5025236.
Choi I, Woo JH, Jou I, Joe EH. PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation. Exp Neurobiol. 2016 Feb;25(1):14-23. doi: 10.5607/en.2016.25.1.14. Epub 2016 Feb 22. PubMed PMID: 26924929; PubMed Central PMCID: PMC4766110.
Choi I, Choi DJ, Yang H, Woo JH, Chang MY, Kim JY, Sun W, Park SM, Jou I, Lee SH, Joe EH. PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes. Mol Brain. 2016 Jan 8;9:5. doi: 10.1186/s13041-016-0186-6. PubMed PMID: 26746235; PubMed Central PMCID: PMC4706723.
[2015]
Choi I, Kim B, Byun JW, Baik SH, Huh YH, Kim JH, Mook-Jung I, Song WK, Shin JH, Seo H, Suh YH, Jou I, Park SM, Kang HC, Joe EH. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun. 2015 Sep 14;6:8255. doi: 10.1038/ncomms9255. PubMed PMID: 26365310; PubMed Central PMCID: PMC4647842.
Choi HK, Choi Y, Kang H, Lim EJ, Park SY, Lee HS, Park JM, Moon J, Kim YJ, Choi I, Joe EH, Choi KC, Yoon HG. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015 Feb 15;24(4):1127-41. doi: 10.1093/hmg/ddu526. Epub 2014 Oct 9. PubMed PMID: 25305081.
[2014]
Jeong HK, Ji KM, Min KJ, Choi I, Choi DJ, Jou I, Joe EH. Astrogliosis is a possible player in preventing delayed neuronal death. Mol Cells. 2014 Apr;37(4):345-55. doi: 10.14348/molcells.2014.0046. Epub 2014 Apr 22. PubMed PMID: 24802057; PubMed Central PMCID: PMC4012084.
[2013]
Choi I, Kim J, Jeong HK, Kim B, Jou I, Park SM, Chen L, Kang UJ, Zhuang X, Joe EH. PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR. Glia. 2013 May;61(5):800-12. doi: 10.1002/glia.22475. Epub 2013 Feb 26. PubMed PMID: 23440919; PubMed Central PMCID: PMC3657120.
Kim J, Byun JW, Choi I, Kim B, Jeong HK, Jou I, Joe E. PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices. Exp Neurobiol. 2013 Mar;22(1):38-44. doi: 10.5607/en.2013.22.1.38. Epub 2013 Mar 31. PubMed PMID: 23585721; PubMed Central PMCID: PMC3620457.