Publications

An up-to-date list of publications can be found on Google Scholar.

Bold: Lane Lab members

2022

Navigating environmental transitions: the role of phenotypic variation in bacterial responses

Spratt M, Lane K

mBio. 2022. e0221222. https://doi.org/10.1128/mbio.02212-22

A multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens

Kudo T, Lane K, Covert MW.

Cell Systems. 2022. S2405 – 4712 (22) 00084-9.  https://doi.org/10.1016/j.cels.2022.02.006

2020

Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation

Macklin DN, Horst TA, Choi H, Ruggero NA, Carrera J, Mason JC, Sun G, Agmon E, DeFelice MM, Maayan I, Lane K, Spangler RK, Gillies TE, Paull ML, Akhter S, Bray SR, Weaver DS, Keseler IM, Karp PD, Morrison JH, Covert MW.

Science. 2020. 369(6502): eaav3751. https://doi.org/10.1126/science.aav3751

2019

Mechanically resolved imaging of bacteria using expansion microscopy

Lim Y, Shiver AL, Khariton M, Lane KM, Ng KM, Bray SR, Qin J, Huang KC, Wang B.

PLoS Biol. 2019. 17(10): e3000268. https://doi.org/10.1371/journal.pbio.3000268

Escalating threat levels of bacterial infection can be discriminated by distinct MAPK and NF-κB signaling dynamics in single host cells

Lane K, Andres-Terre M, Kudo T, Monack DM, Covert MW.

Cell Systems. 2019. 8(3): 183-196.e4. https://doi.org/10.1016/j.cels.2019.02.008

Combinatorial processing of bacterial and host-derived innate immune stimuli at the single-cell level

Gutschow MV, Mason JC, Lane K, Maayan I, Hughey JJ, Bajar BT, Amatya DN, Valle SD, Covert MW.

Molecular Biology of the Cell. 2019. 30(2): 282-292. https://doi.org/10.1091/mbc.E18-07-0423

2017

Measuring signaling and RNA-Seq in the same cell links gene expression to dynamic patterns of NF-κB activation

Lane K*, Van Valen D*, DeFelice MM, Macklin DN, Kudo T, Jaimovich A, Carr A, Meyer T, Pe’er D, Boutet SC, Covert MW. * Equal contribution

Cell Systems. 2017. 4(4): 458-469.e5. https://doi.org/10.1016/j.cels.2017.03.010

2016

Deep learning automates the quantitative analysis of individual cells in live-cell imaging experiments

Van Valen D, Kudo T, Lane K, Macklin DN, Quach NT, DeFelice MM, Maayan I, Tanouchi Y, Ashley EA, Covert MW.

Plos Computational Biology. 2016. 12(11): e1005177. https://doi.org/10.1371/journal.pcbi.1005177