The Dengue Human Immunology Project Consortium employs systems biology and multiparameter phenotyping analyses to characterize the state of the human immune system before and after natural dengue virus infection or vaccination. The study of a well-characterized pediatric cohort in Nicaragua uses multiplex transcriptomic, proteomic, and functional assays and computational analyses to identify novel immune mediators and biological pathways. A centralized knowledge base accelerates studies of human immunity and develops innovative applications for immune-mediated diseases.
This study is funded by a U19 grant from NIH.