Eichner LJ*, Curtis SD, Brun SN, McGuire CK, Gushterova I, Baumgart JT, Trefts E, Ross DS, Rymoff TJ, Shaw RJ*. HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Science Advances. 9 (11), eadd3243 (2023). *co-corresponding
Eichner LJ, Curtis SD, Brun SN, Baumgart JT, Ross DS, Rymoff TJ, Shaw RJ. HDAC3 regulates senescence and lineage specificity in non-small cell lung cancer. bioRxiv doi: https://doi.org/10.1101/2020.10.14.338590 (2021).
Rodon L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. Sci Adv. 5(7), eaaw6455 (2019).
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera L, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC. Cancer Discovery. pii: CD-18-1261 (2019).
Eichner LJ*, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU*. Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models. Cell Metabolism. 29(2), 285-302 (2019). *Equal contribution
Svensson RU, Parker SJ*, Eichner LJ*, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nature Medicine. 22(10), 1108-1119 (2016). *Equal contribution
Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes and Development. 30(5), 535-52 (2016).
Mouchiroud L*, Eichner LJ*, Shaw RJ, Auwerx J. Transcriptional Coregulators: Fine-Tuning Metabolism. Cell Metabolism. 20(1), 26-40 (2014). *Equal contribution
Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V. ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction. Mol Cell Biol. 34(23), 4232-43 (2014).
Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Molecular and Genetic Crosstalks Between mTOR and ERRa are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver. Cell Metabolism. 17(4), 586-98 (2013).
Eichner LJ, Giguère V. Estrogen-related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion. 11(4), 544-552 (2011).
Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, Duguay D, Cermakian N, Giguère V. Genomic Convergence among ERRa, PROX1 and BMAL1 in the Control of Metabolic Clock Outputs. PLoS Genetics. 7(6), e1002143 (2011).
Giguère V, Dufour CR, Eichner LJ, Deblois G, Cermakian N. Estrogen-Related Receptor α, the Molecular Clock, and Transcriptional Control of Metabolic Outputs. Cold Spring Harbor Symposia on Quantitative Biology. 76, 57-61 (2011).
Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J, Giguère V. miR-378∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway. Cell Metabolism. 12(4), 352-361 (2010).
Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK and Giguère V. The homeobox protein Prox1 is a negative modulator of ERRa/PGC-1a bioenergetic functions. Genes & Development. 24(6), 537-42 (2010).
Pascal LE, True LD, Campbell DS, Deutsch EW, Risk M, Coleman IM, Eichner LJ, Nelson PS, Liu AY. Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate. BMC Genomics. 9, 246 (2008).
Deutsch EW, Ball CA, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen J, Davidson D, Eichner LJ, Goo YA, Grimmond S, Henrich T, Johnson MH, Korb M, Mills JC, Oudes A, Parkinson HE, Pascal LE, Quackenbush J, Ramialison M, Ringwald M, Sansone SA, Sherlock G, Stoeckert CJ Jr, Swedlow J, Taylor RC, Walashek L, Zhou Y, Liu AY, True LD. Development of the Minimum Information Specification for In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). OMICS. 10(2), 205-8 (2006).
Oudes AJ, Roach JC, Walashek LS, Eichner LJ, True LD, Vessella RL, Liu AY. Application of Affymetrix array and Massively Parallel Signature Sequencing for identification of genes involved in prostate cancer progression. BMC Cancer. 5, 86 (2005).