2023
Structure and function of the apical PIKKs in double-strand break repair. Jingfei Xu, Noah Bradley and Yuan He. Current Opinion in Structural Biology, 2023
Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation. Anna Talyzina, Yan Han, Chiranjib Banerjee, Susan Fishbain, Alexis Reyes, Reza Vafabakhsh and Yuan He. Molecular Cell. 2023
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Siyu Chen, Alex Vogt, Linda Lee, Tasmin Naila, Ryan McKeown, Alan E Tomkinson, Susan P Lees-Miller and Yuan He. Science Advances. 2023
Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Avinash B Patel, Jinkang Qing, Kelly H Tam, Sara Zaman, Maria Luiso, Ishwar Radhakrishnan and Yuan He. Nature Communications. 2023
2022
Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer. Christopher W Koo, Frank J Tucci, Yuan He and Amy C Rosenzweig. Science. 2022
Structural and functional analysis of the SET3 histone deacetylase complex. Alexis A Reyes, Susan Fishbain and Yuan He. Acta Crystallogr F Struct Biol Commun. 2022
2021
Structural basis of long-range to short-range synaptic transition in NHEJ. Siyu Chen, Linda Lee, Tasmin Naila, Susan Fishbain, Annie Wang, Alan E Tomkinson, Susan P Lees-Miller and Yuan He. Nature, 2021.
Structure of the human Mediator-bound transcription preinitiation complex. Ryan Abdella, Anna Talyzina, Siyu Chen, Carla J Inouye, Robert Tjian and Yuan He. Science, 2021.
Structural insights into the role of DNA-PK as a master regulator in NHEJ. Siyu Chen, James P Lees-Miller, Yuan He and Susan P Lees-Miller. Genome Instab Dis. 2021
Structure and function of chromatin remodelers. Alexis A Reyes, Ryan D Marcum and Yuan He. Journal of Molecular Biology, 2021.
2020
A structural model of the endogenous human BAF complex informs disease mechanisms. Nazar Mashtalir, Hiroshi Suzuki, DanielP Farrell, Akshay Sankar, Jie Luo, Martin Filipovski, Andrew R D’Avino, Roodolph St Pierre, Alfredo M Valencia, Takashi Onikubo, Robert G Roeder, Yan Han, Yuan He, Jeffrey A Ranish, Frank Dimaio, Thomas Walz and Cigall Kadoch. Cell, 2020.
Structural insights into the evolutionarily conserved BAF chromatin remodeling complex. Ryan D Marcum, Alexis A Reyes and Yuan He. Biology, 2020.
Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Yan Han, Alexis A Reyes, Sara Malik and Yuan He. Nature, 2020.
Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation. Ryan Abdella, Megha Aggarwal, Takashi Okura, Robert A Lamb and Yuan He. Proc Natl Acad Sci USA, 2020.
2019
Transcription preinitiation complex structure and dynamics provide insights into genetic diseases. Chunli Yan, Thomas Dodd, Yuan He, John A Tainer, Susan E Tsutakawa and Ivaylo Ivanov. Nature Structural and Molecular Biology, 2019.
2018
Structural visualization of RNA polymerase III transcription machineries. Yan Han, Chunli Yan, Susan Fishbain, Ivaylo Ivanov and Yuan He. Cell Discovery, 2018.
Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation. Ashleigh J Jackobel, Yan Han, Yuan He and Bruce A Knutson. Transcription, 2018.
2017
Structural mechanism of ATP-independent transcription initiation by RNA Polymerase I. Yan Han, Chunli Yan, Thi Hoang Duong Nguyen, Ashleigh J Jackobel, Ivaylo Ivanov, Bruce A Knutson, and Yuan He. eLife, 2017.
Structural insights into the eukaryotic transcription initiation machinery. Eva Nogales, Robert Louder, and Yuan He. Annual Review in Biophysics, 2017.
2016
Cryo-EM in the study of challenging systems: the human transcription pre-initiation complex. Eva Nogales, Robert Louder, and Yuan He. Current Opinion in Structural Biology, 2016.
Eukaryotic transcription initiation machinery visualized at molecular level. Yan Han & Yuan He. Transcription, 2016.
Near-atomic resolution visualization of human transcription promoter opening. Yuan He, Chunli Yan, Jie Fang, Carla Inouye, Robert Tjian, Ivaylo Ivanov, and Eva Nogales. Nature, 2016.
Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Robert K. Louder, Yuan He, José Ramón López-Blanco, Jie Fang, Pablo Chacón, and Eva Nogales. Nature, 2016.
2015
Architecture of the human XPC DNA repair and stem cell coactivator complex. Elisa T Zhang, Yuan He, Patricia Grob, Yick W Fong, Eva Nogales and Robert Tjian. Proc Natl Acad Sci USA, 2015.
2013
Structural visualization of key steps in human transcription initiation. Yuan He, Jie Fang, Dylan J. Taatjes, and Eva Nogales. Nature, 2013.