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Publications

Learn more about the work that we do in the Nicholas Cianciotto Laboratory through our recent publications.

See also PubMed.
  1. Lopez AE, Grigoryeva LS, Barajas A, Cianciotto NP. Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages. Infection and Immunity. 2023 Jul 10:e00072-23.
  2. Lopez AE, Mayoral J, Cianciotto NP. Complete Genome Sequence of Legionella cardiaca Strain H63T, Isolated from a Case of Native Valve Endocarditis. Microbiology Resource Announcements. 2023 Jun 13:e00175-23.
  3. Campbell JA, Cianciotto NP. Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection. Infection and Immunity. 2022 Sep 8:e00369-22

  4. Grigoryeva LS, Cianciotto NP. Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor. PLoS pathogens. 2021 Jul 19;17(7):e1009781.
  5. Nas MY, Gabell J, Cianciotto NP. Effectors of the Stenotrophomonas maltophilia type IV secretion system mediate killing of clinical isolates of Pseudomonas aeruginosa. Mbio. 2021 Jun 29;12(3):e01502-21.
  6. Grigoryeva LS, Rehman S, White RC, Garnett JA, Cianciotto NP. Assay for Assessing Mucin Binding to Bacteria and Bacterial Proteins. Bio-protocol. 2021 Mar 5
  7. Portlock TJ, Tyson JY, Dantu SC, Rehman S, White RC, McIntire IE, Sewell L, Richardson K, Shaw R, Pandini A, Cianciotto NP, Garnett JA Structure, Dynamics and Cellular Insight Into Novel Substrates of the Legionella pneumophila Type II Secretion System Frontiers in Molecular Biosciences. 2020 June
  8. Rehman S, Grigoryeva LS, Richardson KH, Corsini P, White RC, Shaw R, Portlock TJ, Dorgan B, Zanjani ZS, Fornili A, Cianciotto NP, Garnett JA Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation PLoS Pathogens. 2020 May; 16(5)
  9. Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography Nature Microbiology. 2019 ;  4, 12, (2101-2108), 10.1038/s41564-019-0603-6)
  10. Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ In vivo structure of the Legionella type II secretion system by electron cryotomography Nature Microbiology. 2019 Dec; 4(12): 2101-2108.
  11. White RC, Truchan HK, Zheng H, Tyson JY, Cianciotto NP  Type II Secretion Promotes Bacterial Growth within the Legionella-Containing Vacuole in Infected Amoebae.  Infect Immun  2019 Aug 12;. pii:IAI.00374-19
  12. Nas MY, White RC, DuMont AL, Lopez AE, Cianciotto NP  Stenotrophomonas maltophilia Encodes a VirB/VirD4 Type IV Secretion System That Modulates Apoptosis in Human Cells and Promotes Competition against Heterologous Bacteria, Including Pseudomonas aeruginosa.  Infect Immun  2019 Sep;87(9). pii:e00457-19
  13. White RC, Cianciotto NP  Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: the Legionella type II secretion paradigm.  Microb Genom  2019 Jun;5(6). doi:10.1099/mgen.0.000273
  14. Burnside DM, Cianciotto NP  Analysis of Iron Requirements and Siderophore Production.  Methods Mol Biol  2019;1921:3-19. doi:10.1007/978-1-4939-9048-1_1
  15. White RC, Gunderson FF, Tyson JY, Richardson KH, Portlock TJ, Garnett JA, Cianciotto NP  Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas.  MBio  2018 04 17;9(2). pii:e00528-18
  16. Nas MY, Cianciotto NP  Stenotrophomonas maltophilia produces an EntC-dependent catecholate siderophore that is distinct from enterobactin.  Microbiology  2017 11;163(11):1590-1603. doi:10.1099/mic.0.000545
  17. DuMont AL, Cianciotto NP  Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells.  Infect Immun  2017 12;85(12). pii:e00544-17
  18. Truchan HK, Christman HD, White RC, Rutledge NS, Cianciotto NP  Type II Secretion Substrates of Legionella pneumophila Translocate Out of the Pathogen-Occupied Vacuole via a Semipermeable Membrane.  MBio  2017 06 20;8(3). pii:e00870-17
  19. Cianciotto NP, White RC  Expanding Role of Type II Secretion in Bacterial Pathogenesis and Beyond.  Infect Immun  2017 05;85(5). pii:e00014-17
  20. Mallama CA, McCoy-Simandle K, Cianciotto NP  The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages.  Infect Immun  2017 04;85(4). pii:e00897-16
  21. White RC, Cianciotto NP  Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms.  Infect Immun  2016 Dec;84(12):3313-3327
  22. O’Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR  Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila.  Infect Immun  2016 08;84(8):2185-2197. doi:10.1128/IAI.01306-15
  23. Aubi O, Flydal MI, Zheng H, Skjærven L, Rekand I, Leiros HK, Haug BE, Cianciotto NP, Martinez A, Underhaug J  Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.  J Med Chem  2015 Nov 12;58(21):8402-12. doi:10.1021/acs.jmedchem.5b01589
  24. Burnside DM, Wu Y, Shafaie S, Cianciotto NP  The Legionella pneumophila Siderophore Legiobactin Is a Polycarboxylate That Is Identical in Structure to Rhizoferrin.  Infect Immun  2015 Oct;83(10):3937-45. doi:10.1128/IAI.00808-15
  25. DuMont AL, Karaba SM, Cianciotto NP  Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2.  Infect Immun  2015 Oct;83(10):3825-37. doi:10.1128/IAI.00672-15
  26. Cianciotto NP  An update on iron acquisition by Legionella pneumophila: new pathways for siderophore uptake and ferric iron reduction. Future Microbiol  2015;10(5):841-51. doi:10.2217/fmb.15.21
  27. Gunderson FF, Mallama CA, Fairbairn SG, Cianciotto NP  Nuclease activity of Legionella pneumophila Cas2 promotes intracellular infection of amoebal host cells.  Infect Immun  2015 Mar;83(3):1008-18. doi:10.1128/IAI.03102-14
  28. Tyson JY, Vargas P, Cianciotto NP  The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.  Microbiology  2014 Dec;160(Pt 12):2732-44. doi:10.1099/mic.0.082750-0
  29. Portier E, Zheng H, Sahr T, Burnside DM, Mallama C, Buchrieser C, Cianciotto NP, Héchard Y  IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages.  Environ Microbiol  2015 Apr;17(4):1338-50. doi:10.1111/1462-2920.12604