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Lab Members

 

 

 

Daniel J Brat, MD, PhD

Daniel J Brat, MD, PhD

Chair and Magerstadt Professor of Pathology

Subhas Mukherjee, PhD

Subhas Mukherjee, PhD

Research Assistant Professor

Subhas is from India where he received his Bachelors and his Masters degree from Calcutta University. He then travelled to US with an overseas study travel award and received his PhD in Genetics from Howard University as an Exemplar Graduate Student. His PhD thesis revealed genetics of mitochondrial oxidative stress in regulating cell growth and aging using Drosophila as a model system. He then accepted a postdoctoral position at Emory University and implemented his knowledge in understanding the enigmatic behavior of high grade brain tumor stem cells. His primary research focus is to investigate the self-renewing properties of glioma stem cells (GSCs), the driving force behind glioblastoma (GBM) growth, recurrence and therapeutic resistance. His larger goals in biomedical research are to develop and use models of GBM, including Drosophila and mouse, to uncover mechanisms and to translate the findings to human GBM therapeutics.

 

 

Steven Markwell, PhD

Steven Markwell, PhD

Post Doctoral Fellow

Steve is a Chicagoland native and received his B.S. in Chemistry and Molecular and Cellular Biology at the University of Illinois. He received his Ph.D. in Cancer Cell Biology from West Virginia University in 2018, with his thesis research elucidating a novel regulatory mechanism governing invasive dynamics in head and neck cancer. He continues to investigate complex tumor micro-environmental interactions that drive tumor progression as a Post-doctoral Fellow in the Brat Lab, where he focuses on immune mediators of therapeutic resistance, progression, and disease recurrence in glioblastoma. He is developing a novel cancer model involving intravital imaging in mice seeking to expand our understanding of the intricate coordination between glioblastoma stem cells, tumor-associated macrophages, and microglial cells following intratumoral thrombosis in the glioblastoma micro-environment.

 

 

 

Nitya Sharma, PhD

Nitya Sharma, PhD

Post Doctoral Fellow

Originally from Florida, Nitya attended Emory University in Atlanta where she received a B.S. in Neuroscience and Behavioral Biology. She continued her studies in Atlanta, first receiving an M.S. in Bioinformatics from Georgia Institute of Technology and then a Ph.D. from Emory in Genetics and Molecular Biology. Her thesis work focused on determining the transcriptional regulators responsible for both androgen deprivation therapy response and metastasis in prostate cancer. As a post-doctoral fellow, Nitya investigates the fundamental relationship between stemness and quiescence in radiation resistant cell populations and how this influences recurrence in glioblastoma. ​

 

 

Prerana Mantri

Prerana Mantri

Graduate Student

Prerana grew up in India and received her B.S. in Biomedical Science from Florida Institute of Technology in Melbourne, FL. Her undergraduate research was focused on analyzing metabolomics data and the change in function of plant enzymes in response to chemical signals produced by mutualistic bacteria in the rhizosphere. She is currently doing her M.S. in Biotechnology at Northwestern University. In the Brat Lab, she is working under Nitya Sharma to study the fundamental relationship between stemness and quiescence and their relation to radiation resistance in glioblastomas.

 

 

Cheryl L Olson

Cheryl L Olson

Research Lab Manager

Leah Broger

Leah Broger

Undergraduate Student

Hannah Lee

Hannah Lee

Undergraduate Student

Karla Acosta

Karla Acosta

Undergraduate Student