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Research

Vascular Regeneration

Peripheral Artery Disease

  • Autologous cell-based therapy for PAD patients
  • Advanced cell and biomolecule delivery with biomaterials 
  • Mechanistic investigation of vascular and muscle regeneration

Collaborators: Guillermo Ameer, Igor Efimov, Clara Peek

Vascular Remodeling and Calcification

  • Mechanistic investigation of pathological vascular remodeling
  • Vascular device development
  • Vascular smooth muscle cell differentiation 

Collaborators: Karen Ho, Yogesh Goyal, Jonathan Rivnay

Remodeling
AAA

Abdominal Aortic Aneurysm

  • Mechanistic investigation with animal models and human tissues
  •  Regenerative therapeutics development

Collaborators: Mark Eskandari

Vascular Inflammation and Thrombosis

  • In vitro disease modeling and drug screening
  • Targeted antithrombotic delivery 

Collaborators: Guillermo Ameer, Mark Eskandari

thrombosis

Research Technologies

iPSCs

Stem Cell Engineering

Induced pluripotent stem cells
Mesenchymal stem cells
Cell-based products

Biomaterials

Biomaterial Design

Extracellular matrix-derived materials
Biodegradable polymers
Bioactive peptides

Non-invasive Imaging

Non-invasive Imaging

Nuclear imaging for non-invasive live cell tracking
Vascular imaging for blood perfusion and calcification

surgical models

Surgical Models of Vascular Diseases

Hindlimb ischemia for PAD
AngII infusion for AAA
Carotid balloon injury for neointimal hyperplasia

Publications

  1. Su J, Wang H, Haney C, Ameer G, Jiang B. Enabling Non-invasive Tracking of Vascular Endothelial Cells Derived from Induced Pluripotent Stem Cells Using Nuclear Imaging. Cardiovascular Engineering and Technology. 2024 Apr 23:1-1.
  2. Chao C, Dang C, Reddy N, Alharbi S, Doan J, Karthikeyan A, Applewhite B, Jiang B. Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling. JVS-Vascular Science. 2024 Jan 1;5:100202.
  3. Jiang, B.*, Wang X, Rivera Bolanos, Duan C, and Ameer, G.A. Generation of Autologous Vascular Endothelial Cells for Patients with Peripheral Artery Disease. Journal of Cardiovascular Translational Research. 2023; doi: 10.1007/s12265-023-10452-z.
  4. Gorashi, R, Rivera-Bolanos, N, Dang, C, et al. Modeling diabetic endothelial dysfunction with patient-specific induced pluripotent stem cells. Bioeng Transl Med. 2023;e10592. doi:10.1002/btm2.10592
  5. Wang, X., Agrawal, V., Dunton, C.L. et al. Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei. Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-023-01053-x
  6. Brown TK, Alharbi S, Ho KJ, Jiang B. Prosthetic vascular grafts engineered to combat calcification: Progress and future directions. Biotechnology and Bioengineering. 2023;120:953-69.
  7. Petty AJ, Keate RL, Jiang B, Ameer GA, Rivnay J. Conducting Polymers for Tissue Regeneration in Vivo. Chemistry of Materials. 2020; 32 (10), 4095-4115.
  8. Li W, Fu Y, Jiang B, Lo AY, Ameer GA, Barnett C, Wang B. Polymer Integrated Amnion Scaffold Significantly Improves Cleft Palate Repair. Acta Biomaterialia. 2019 Jul 1;92:104-14.
  9. Wang X, Rivera-Bolanos N, Jiang B*, Ameer GA. Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine. Advanced Functional Materials. Invited review. * co-corresponding author. 2019 Jun;29(23):1809009.
  10. Jiang B, Suen R, Wang JJ, Zhang ZJ, Wertheim JA, Ameer GA. Vascular Scaffolds with Enhanced Antioxidant Activity Inhibit Graft Calcification. Biomaterials. 2017 Nov; 144:166-175.
  11. Jiang B*, Wu Y*, Haney C, Duan C, Ameer GA. Assessment of an Engineered Endothelium via Single-photon Emission Computed Tomography. Biotechnology and Bioengineering. 2017 Oct;114(10):2371-2378. * Co-first Authors
  12. Jiang B, Suen R, Wertheim JA, Ameer GA. Targeting Heparin to Collagen within Extracellular Matrix Significantly Reduces Thrombogenicity and Improves Endothelialization of Decellularized Tissues. Biomacromolecules. 2016 Nov 29;17(12):3940-8.
  13. Jiang B, Suen R, Wang JJ, Zhang ZJ, Wertheim JA, Ameer GA. Mechanocompatible Polymer-Extracellular Matrix Composites for Vascular Tissue Engineering. Advanced Healthcare Materials. 2016 Jul;5(13):1594-605. Featured Article.
  14. Appel AA, Larson JC, Jiang B, Zhong Z, Anastasio MA, Brey EB. X-ray Phase Contrast Allows Three-Dimensional, Quantitative Imaging of Hydrogel Implants. Annals of Biomedical Engineering. 2016 Mar;44(3):773-81. Cover Art.
  15. Jiang B, Jen M, Perrin L, Wertheim JA, Ameer GA. SIRT1 Overexpression Maintains Cell Phenotype and Functions of Endothelial Cells Derived from Induced Pluripotent Stem Cells. Stem Cell and Development. 2015 Dec 1;24(23):2740-2745.
  16. Akar B, Jiang B, Somo SI, Appel AA, Larson JC, Tichauer KM, Brey EM. Biomaterials with Persistent Growth Factor Gradients in vivo Accelerate Vascularized Tissue Formation. 2015 Dec; 72: 61-73.
  17. Jiang B, Perrin L, Kats D, Meade T, Ameer GA. Enabling Non-invasive Assessment of an Engineered Endothelium on ePTFE Vascular Grafts without Increasing Oxidative Stress. 2015 Nov; 69: 110-120.
  18. Jiang B, Akgun B, Lam RC, Ameer GA, Wertheim JA. A Polymer-Extracellular Matrix Composite with Improved Thromboresistance and Recellularization Properties. Acta Biomaterialia. 2015 May; 18: 50-58.
  19. Engel H, Kao SW, Larsson JC, Uriel S, Jiang B, Brey EM, Cheng MH. Investigation of Dermis-Derived Hydrogels for Wound Healing Applications. Biomedical Journal. 2015 Jan-Feb; 38(1): 58-64.
  20. McQuilling JP, Arenas-Herrera J, Pareta R, Sivanandane S, Wofford W, Khanna O, Jiang B, Brey EM, Orlando G, Farney AC, Opara EC. Islet function and angiogenic protein delivery from multilayer microcapsules. Biomaterials and Biomedical Engineering. 2014; 1(1):27-39.
  21. Jiang B, Akar B, Waller TM, Larson JC, Appel AA, Brey EM. Design of a composite biomaterial system for tissue engineering applications. Acta Biomaterialia. 2014 Mar; 10(3): 1177–86.
  22. Drapala PW, Jiang B, Chiu YC, Mieler WF, Brey EM, Kang-Mieler JJ, Pérez-Luna VH. The Effect of Gluthathione as Chain Transfer Agent in PNIPAAm based Thermo-responsive Hydrogels for Controlled Release of Proteins. Pharmaceutical Research. 2014 Mar; 31(3):742-53
  23. Jiang B, Zhang G, Brey EM. Dual Delivery of Chlorhexidine and Platelet-Derived Growth Factor-BB for Enhanced Wound Healing and Infection Control. Acta Biomaterialia. 2013 Feb; 9(2): 4976-84.
  24. Jiang B, Waller TM, Larson JC, Appel AA, Brey EM. Fibrin Loaded Porous Poly(ethylene glycol) Hydrogels Induce Vascular Network Formation. Tissue Engineering Part A. 2013 Jan;19(1-2):224-34. Cover Art.
  25. Jiang B, Larson JC, Drapala PW, Pérez-Luna VH, Kang-Mieler JJ, Brey EM. Investigation of Lysine Acrylate Containing Poly (N-isopropylacrylamide) Hydrogels as Wound Dressings in Normal and Infected Wounds. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012 Apr; 100(3):668-76.
  26. McQuilling JP, Arenas-Herrera J, Childers C., Pareta RA., Khanna O, Jiang B., Brey EM, Farney AC., Opara EC. New Alginate Microcapsule System for Angiogenic Protein Delivery and Immunoisolation of Islets for Transplantation in the Rat Omentum Pouch. Transplantation Proceedings. 2011 Nov;43(9):3262-4.
  27. Jiang B, Brey E. Formation of Stable Vascular Networks in Engineered Tissues. In: Daniel Eberli (Ed.) Regenerative Medicine and Tissue Engineering – Cells and Biomaterials, InTech, 2011. P.477-502.