Wignall Lab

Home

Above: High-resolution imaging of bipolar and monopolar oocyte spindles in C. elegans during Meiosis I and II

shapeimage_1

 

Proper segregation of chromosomes during mitosis and meiosis depends upon the formation of a bipolar spindle.  In most cell types, duplicated centrosomes contribute to spindle assembly by nucleating microtubules and helping to organize the two poles.  However, during meiosis in female animals the centrosomes are degraded prior to the meiotic divisions, and therefore oocyte spindles form in their absence.  We are interested in understanding how these acentrosomal spindles form, how they are organized, and how they promote proper chromosome partitioning.  To address these questions, we combine high-resolution microscopy with genetic, genomic, and biochemical approaches in the nematode C. elegans.

 

 

Looking for something?

Use the form below to search the site:

Still not finding what you're looking for? Drop a comment on a post or contact us so we can take care of it!

Visit our friends!

A few highly recommended friends...

Archives

All entries, chronologically...