Super Resolution Plasmon Microscopy

Single particle tracking using plasmonic nanoparticles is a valuable tool for understanding biological processes ranging from membrane fusion, cell signaling, and protein compartmentalization.  Solid supported lipid bilayers have proven to be a useful model system for detailed mechanistic studies.  We have recently carried out a study in which gangleoside lipids were incoporated into solid supported bilayers in high concentrations.  The bilayers also contained a small amount of positively charged lipids with which negatively charged nanoparticles were bound and tracked using the appartus shown below.  A drastic difference in the diffusion properties of the nanoparticles in bilayers containing 5% Vs no gangleoside lipids was observed.  The measurements confirm that the gangleoside lipids most likely form small clusters in the solid supported bilayers, which is believed to inhibit the binding of the Cholera Toxin protein.


Recent Publications:

“Single Plasmonic Nanoparticle Tracking Studies of Solid Supported Bilayers with Gangleoside Lipids,” L. B. Sagle, L. Ruvuna, J. M. Bingham, C. Liu, P. S. Cremer, and R. P. Van Duyne, J. Am. Chem. Soc., 134, 15832–15839 (2012).


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  • Professor Richard Van Duyne

    Additional Information

    Discoverer of Surface-enhanced Raman Spectroscopy (1977)
    Inventor of Nanosphere Lithography (1995) & Localized Surface Plasmon Resonance Spectroscopy (2000)

  • Group Members

    Professor Van Duyne has, in his career to date, advised a total of 87 graduate students and 47 postdoctoral fellows. Every year, Professor Van Duyne gives a talk to introduce new graduate students to our research. The 2017 seminar slides are available here.

  • News

    Professor Van Duyne was recently named a Vannevar Bush Faculty Fellow by the U.S. Department of Defense to conduct "high risk, high payoff" basic scientific research. Read more here