SERS Biosensing

The focus of SERS biosensing in the Van Duyne group is to develop SERS platforms for in vivo sensing of physiologically-relevant analytes. The early diagnosis and treatment of illness and infections would benefit enormously from systems that provide rapid identification of small and large molecules of biological interest in a label-free, no-sample processing, multiplexed manner. We have previously demonstrated in vivo sensing capabilities for glucose detection, to aid in non-invasive testing of glucose levels in diabetic individuals. We are developing SERS nanoplatforms based on noble metal nanoparticle assemblies with maximum possible sensitivity (viz., SERS enhancement factors (EFs) in the 108-109 range). Novel surface chemistries and outermost surface functionalization will be developed to bind or partition target analytes at clinically relevant concentrations while simultaneously excluding interferences from other molecules in interstitial fluid (ISF).

Emma Vander Ende, 4th year graduate student
Ji Eun Park, 3rd year graduate student

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  • Professor Richard Van Duyne

    Additional Information

    Discoverer of Surface-enhanced Raman Spectroscopy (1977)
    Inventor of Nanosphere Lithography (1995) & Localized Surface Plasmon Resonance Spectroscopy (2000)

  • Group Members

    Professor Van Duyne has, in his career to date, advised a total of 87 graduate students and 47 postdoctoral fellows. Every year, Professor Van Duyne gives a talk to introduce new graduate students to our research. The 2017 seminar slides are available here.

  • News

    Professor Van Duyne was recently named a Vannevar Bush Faculty Fellow by the U.S. Department of Defense to conduct "high risk, high payoff" basic scientific research. Read more here