Group Members

Meade Group Members

*denotes Graduate Students **denotes Postdoctoral Researchers

 

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Macrenaris, Keith Research Asst. Professor, CAMI & QBIC

In a managerial capacity, I’m in charge of two BSL-2 level cell and tissue culture rooms for approximately 30 graduate and undergraduate students and postdoctoral fellows, as well as managing and running a bioluminescent imaging suite equipped with a IViS Spectrum in vivo bioluminescence/fluorescence analyzer for approximately 60 users.

B.S., Developmental Biology, University of Rochester 2002
Ph.D., Biological Sciences, Northwestern University, 2009

Bajema, Liz *Chemistry

I am seeking to attach our group’s Co(III) Schiff base (Co-sb) inhibitor to a gold nanoparticle in order to improve cell uptake and allow activatable release of the inhibitory agent. By shining laser light of the appropriate wavelength on the gold nanoparticles, the Co-sb inhibitory agent will be released. I am investigating the potential of this system to treat basal cell carcinoma (skin cancer) tumors.

B.S. Chemistry and Religious Studies, Saint Mary’s College (IN), 2011

NIH Ruth L. Kirschstein National Research Service Award (NRSA), 2013
Brady Scholar’s Program in Ethics and Civic Life, Graduate Fellow, 2013
NIH Clinical Translation Research Course, 2015

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Brue, Christopher *Chemistry

My research involves the development and characterization of cobalt-schiff base complexes to be used as potential therapeutics for Altzheimer’s Disease.

B.S. Chemistry and History, The Ohio State University, 2015

Caldwell, Michael *Chemistry

My research involves the synthesis of MRI probes that target the progesterone and estrogen receptors. These receptors have been implicated in numerous important pathways and diseases, most notably in breast cancer, and provide clinically relevant handles for tumor imaging and biopsy-free histology.

B.S. Chemistry, Michigan State University, 2013

Chemistry of Life Processes Institute Pre-Doctoral Fellowship, 2014, 2015
NIGMS Career Development Conference at Vanderbilt University, 2015
Alumnae Grant, 2017
Management for Scientists and Engineers Program, 2017

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Johnson, Andrew *Chemistry

I am seeking to synthesize new bio-activated MR contrast agents. Currently I am focusing on developing a contrast agent for selective imaging of superoxide in-vivo

B.A. Chemistry, Central College, 2015

National Science Foundation (NSF) Graduate Research Fellowship Honorable Mention, 2016

Kim, Joy *Biomedical Engineering

My research involves the application and development of cobalt(III) Schiff base complexes as potential therapeutics for Alzheimer’s disease.  Specifically, I am looking at its effects on amyloid-beta aggregation through the use of molecular dynamic simulations.

B.S. Biomedical Engineering, Georgia Tech, 2016

Krueger, Ruby *Chemistry

The goal of my research is to visualize pathological biomarkers using MRI. In order to do so, I am investigating a variety of bioorthogonal ligation reactions to localize MRI-activated gadolinium(III) chelates inside and on the surface of disease-state cells, with the long-term aim of imaging cancer in vivo.

B.S. Biochemistry, University of California, Santa Barbara, 2009

Alumnae Grant, 2014

Li, Hao *Chemistry

The goal of my main project is to develop dual activatable MR and fluorescent probes that will enable the sensitive and selective detection of biomarkers in vivo via dual modality imaging. This approach synergistically combines the deep-tissue penetration of MRI and the high sensitivity of fluorescence imaging. My side project is to develop photocaged TEM “markers” that upon two-photon excitation will release a polyfluorous compound identifiable under TEM, generating an accurate map for the light excitation site and therefore the exact position where photocaged neurotransmitters are released. These TEMarkers will enable us to correlate neurotransmitter release to growth of each individual synapse.

B.S. Chemistry (Magna Cum Laude), University of California, Irvine, 2014
M.S. Chemistry, University of Illinois, Urbana-Champaign, 2016

Lilley, Laura *Chemistry

My research involves the synthesis of highly functionalized biologically activated MR contrast agents.

B.S. Chemistry and Biochemistry, Warren Wilson College, 2011

Donald E. Smith Teaching Award, 2014
NIGMS Career Development Conference at Vanderbilt University, 2015
Gelewitz Award, 2016

McLeod, Shaunna *Chemistry

My research involves the synthesis and characterization of bioactivatable MRI contrast agents.

B.S. Chemistry and B.A. Mathematics, State University of New York at Buffalo, 2015

National Science Foundation (NSF) Graduate Research Fellowship, 2017

Preslar, Adam *Chemistry

My research, at the convergence of self-assembly and imaging, is in collaboration between the Stupp and Meade groups and involves developing peptide amphiphile matrices designed for regenerative medicine applications which have been modified for Magnetic Resonance Imaging augmentation. Bringing Meade group imaging expertise in concert with Stupp group self-assemby experience, we are generating new, multifunctional biomaterials that offer a suite of medical applications.

B.S. Chemistry and Asian Studies, University of North Carolina at Chapel Hill, 2010
Ph.D. Chemistry, Northwestern University, 2016

Ram Mohan, Nikhil *MSTP

My research involves creating a multifunctional nanodiamond complex for targeted, image-guided chemotherapeutic delivery using in vitro and in vivo models of breast cancer.

B.S. Applied Mathematics & Statistics, Psychology, Johns Hopkins University, 2008
M.S.E. Applied Mathematics & Statistics, Johns Hopkins University, 2009

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Roberts, Kaleigh *MSTP

My research involves the application of cobalt(III) Schiff base complexes as potential therapeutics for Alzheimer’s disease.  Specifically, I am looking at effects on amyloid-beta aggregation, generation of ROS, and downstream cellular effects in primary neuronal culture.

B.S. Bioengineering, UIUC

Alumnae Grant, 2014
DOD Fellowship, 2016

Sponenburg, Rebecca *Chemistry

My research involves the synthesis and optimization of Cobalt(III) Schiff-base complexes to be used in light-activated prodrug strategies for protein inhibition.

B.S. Chemistry and Philosophy, Gettysburg College, 2014

Biotech Training Grant, 2016

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Vistain, Luke *IBiS

My research involves the use of HaloTag and HaloTag-targeted MRI contrast agents to detect gene expression.  Through a collaboration with Professor Josh Leonard, we are attempting to develop a cell-based sensor that will report on interleukin-10 concentration in vivo by producing MRI contrast.

B.A. Biochemistry, NYU, 2007

NIH Ruth L. Kirschstein National Research Service Award (NRSA), 2012

 

Undergraduates

 

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 zer keen
 Baker, Hal

Hal started in the fall of 2014.  He is working with graduate student Liz Bajema on the development of transition metal complexes as protein inhibitors for targeted therapies.

Summer Undergraduate Research Grant, 2015
Chicago Area Undergraduate Research Symposium, 2015
Fletcher URG Prize Finalist, 2015
Undergraduate Research Grant, 2016

Chia, Zer Keen

Zer Keen is a chemistry undergraduate who started in the spring of 2015. He is working with graduate student Laura Lilley to develop zero-background MRI contrast agents.

McCormick Gateway Research Award, 2015-2016
Undergraduate Research Grant, 2016
Chemistry of Life Processes Lambert Fellowship, 2016-2018
Honorable Mention, Chicago Area Undergraduate Research Symposium, 2017


Abbey Filicko
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 Filicko, Abbey

Abbey started in the summer of 2015. She is working with graduate student Nikhil Ram Mohan to develop nanodiamond complexes that can target molecular imaging and chemotherapeutic agents to triple negative breast cancer tumors in in vitro and in vivo models.

WCAS Summer Undergraduate Research Grant, 2015

 Lombardo, Stefanie

Stefanie started in the spring of 2014. She worked with graduate student Ruby Kreuger to investigate a variety of bioorthogonal ligation reactions to localize MRI-activated gadolinium(III) chelates inside and on the surface of disease-state cells, with the long-term aim of imaging cancer in vivo.

WCAS Summer Undergraduate Research Grant, 2014
Chemistry of Life Processes-CAURS Award, 2015-2016

 

 

Colin Lynch
 anna preston
 Lynch, Colin

Colin started in the spring of 2015. He is working with postdoc Justin Massing on developing a targeted-reporter MR agent for multi-marker imaging, allowing eventual disease diagnosis and prognosis non invasively.

WCAS Summer Undergraduate Research Grant, 2015
Undergraduate Research Grant, 2016
Chemistry of Life Processes Lambert Fellowship, 2016-2018
Chicago Area Undergraduate Research Symposium, 2017

 Preston, Anna

Anna started in the spring of 2015. She is working with graduate student Kaleigh Roberts on the application of cobalt(III) Schiff base complexes as potential therapeutics for Alzheimer’s disease.

Summer Undergraduate Research Grant, 2015
Fletcher URG Prize Finalist, 2015
WCAS Summer Undergraduate Research Grant Award, 2016
Chicago Area Undergraduate Research Symposium, 2017

 
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Varelas, Eleni

Eleni started in the spring of 2016. She is working with graduate student Kaleigh Roberts on the application of cobalt(III) Schiff base complexes as potential therapeutics for Alzheimer’s disease and the development of TEM contrast agents for investigating synaptogenesis.

Chemistry of Life Processes Summer Scholar, 2016
Undergraduate Research Grant, 2017
Chicago Area Undergraduate Research Symposium, 2017

 

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Chemistry at Northwestern University