New paper: Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells

We’re very excited to share our latest work, now published in Nature Biomedical Engineering! Here, we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles. Congratulations to Dr. Devin Stranford and Beth. Check out the paper here and check out a press article about the paper here!

New preprint: HaloTag display enables quantitative single-particle characterization and functionalization of engineered extracellular vesicles

We’re excited to announce our recent work developing a method using flexible HaloTag labeling to absolutely quantify surface protein loading at the individual EV level, providing new insights into EV heterogeneity. An interesting new insight is that existing methods can substantially underestimate surface display. Congratulations to Roxi and Devin. Check out the preprint here!

New paper: Comparative evaluation of synthetic cytokines for enhancing production and performance of NK92 cell-based therapies

We’re excited to share our latest work focused on evaluating synthetic cytokines to enhance the production and performance of promising off-the-shelf cell therapies for treating cancer. We engineered natural killer-like NK92 cells to express six synthetic cytokines and evaluated their utility for driving expansion, cancer cell killing, and resistance to tumor microenvironmental conditions. Congratulations to Simrita, Patrick, Roxi, and Iva. Check out the paper here!