We’re excited to share our recent work developing genetically-encoded biosensors for use in red blood cells and validating their function in living animals. Congratulations to Dr. Taylor Dolberg and Taylor Gunnels. Check out the paper here!
New preprint: Conversion of natural cytokine receptors into orthogonal synthetic biosensors
We’re excited to share our latest work in which we coopt naturally evolved receptor-ligand interactions and integrate them with self-contained signaling modules to build synthetic receptors that are well-suited to creating customized cellular therapies. Congratulations to Dr. Hailey Edelstein and Amparo. Check out the preprint here!
Roxi Mitrut successfully defends her Ph.D. dissertation. Congratulations, Dr. Mitrut!
New paper: Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells
We’re very excited to share our latest work, now published in Nature Biomedical Engineering! Here, we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles. Congratulations to Dr. Devin Stranford and Beth. Check out the paper here and check out a press article about the paper here!
New preprint: HaloTag display enables quantitative single-particle characterization and functionalization of engineered extracellular vesicles
We’re excited to announce our recent work developing a method using flexible HaloTag labeling to absolutely quantify surface protein loading at the individual EV level, providing new insights into EV heterogeneity. An interesting new insight is that existing methods can substantially underestimate surface display. Congratulations to Roxi and Devin. Check out the preprint here!
Simrita Deol successfully defends her Ph.D. dissertation. Congratulations, Dr. Deol!
New Paper: Teaching systematic, reproducible model development using synthetic biology
We’re excited to share our recent work developing a resource for teaching mathematical model development in synthetic biology, with associated open-source teaching materials. The teaching module makes use of our previously published GAMES tutorial. Congratulations to Dr. Kate Dray and Katie, as well as our collaborator, Dr. Julius Lucks. Check out the paper here!
New paper: Comparative evaluation of synthetic cytokines for enhancing production and performance of NK92 cell-based therapies
We’re excited to share our latest work focused on evaluating synthetic cytokines to enhance the production and performance of promising off-the-shelf cell therapies for treating cancer. We engineered natural killer-like NK92 cells to express six synthetic cytokines and evaluated their utility for driving expansion, cancer cell killing, and resistance to tumor microenvironmental conditions. Congratulations to Simrita, Patrick, Roxi, and Iva. Check out the paper here!
New preprint: Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
We’re excited to share our recent collaboration with the Kamat Lab, exploring how lipid-protein interactions may be leveraged to direct proteins into extracellular vesicles. Congratulations Taylor, Hailey, and our excellent collaborators Justin and Dr. Neha Kamat of the Kamat Lab. Check out the preprint here!