2016

Yang R, Kerschner JL, Harris A. Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function. Biochim Biophys Acta. 2016 Apr;1859(4):591-8. doi: 10.1016/j.bbagrm.2016.02.005. Epub 2016 Feb 6.

Browne JA, Yang R, Leir SH, Eggener SE, Harris A. Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions. Mol Hum Reprod. 2016 Feb;22(2):69-82.

Browne JA, Yang R, Eggener SE, Leir SH, Harris A. HNF1 regulates critical processes in the human epididymis epithelium. Mol Cell Endocrinol. 2016 Apr 15;425:94-102. doi: 10.1016/j.mce.2016.01.021. Epub 2016 Jan 22.

2015

Yang R, Kerschner JL, Gosalia N, Neems D, Gorsic LK, Safi A, Crawford GE, Kosak ST, Leir SH, Harris A. Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. Nucleic Acids Res. 2016 Apr 20;44(7):3082-94. doi: 10.1093/nar/gkv1358. Epub 2015 Dec 15.

Browne JA, Yang R, Leir SH, Eggener SE, Harris A. Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions. Mol Hum Reprod. 2016 Feb;22(2):69-82. doi: 10.1093/molehr/gav066. Epub 2015 Nov 26.

Stolzenburg L, Wachtel S, Dang H, Harris A. microRNA-1343 attenuates pathways of fibrosis by targeting the TGF-β receptors. Biochemical Journal. 2016 Feb 1;473(3):245-56. doi: 10.1042/BJ20150821. Epub 2015 Nov 5.

Cai Z, Palmai-Pallag T, Khuituan P, Mutolo MJ, Boinot C, Liu B, Scott-Ward TS,Callebaut I, Harris A, Sheppard DN. Impact of the F508del mutation on ovine CFTR, a Cl(-) channel with enhanced conductance and ATP-dependent gating. J Physiol.2015 Jun 1;593(11):2427-46.

Gosalia N, Harris A. Chromatin Dynamics in the Regulation of CFTR Expression. Genes (Basel). 2015 Jul 13;6(3):543-58.

Gosalia N, Yang R, Kerschner JL, Harris A. FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells. Physiol Genomics. 2015 Jul;47(7):290-7.

Leir SH, Browne JA, Eggener SE, Harris A. Characterization of primary cultures of adult human epididymis epithelial cells. Fertil Steril. 2015 Mar;103(3):647-54.

Zhang Z, Leir SH, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015 Mar;52(3):387-96.

2014

Browne JA, Yang R, Song L, Crawford GE, Leir SH, Harris A. Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. Mol Hum Reprod. 2014 Dec;20(12):1198-207.

Fossum, S.L., Mutolo, M.J., Yang, R.J., Dang, H., O’Neal, W.K., Knowles, M.R., Leir, S-H., Harris, A. (2014) Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells. Nucl. Acids. Res. 42:13588-13598. Epub Nov 20th.

Gosalia, N, Neems, D, Kerschner, JL, Kosak,S, Harris, A (2014) Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus. Nucl. Acids. Res. 42:9612-22. Epub July 31st

Browne JA, Harris A, Leir SH. An optimized protocol for isolating primary epithelial cell chromatin for ChIP. PLoS One. 2014 Jun 27;9(6).

Kerschner, JL, Gosalia, N, Leir, S-H and Harris, A. (2013) Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells. Epigenetics. 9:557-65. Epub 2014 Jan 17.

2013

Clementz AG, Mutolo MJ, Leir SH, Morris KJ, Kucybala K, Harris H, Harris A. Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells. PLoS One. 2013 Aug 22;8(8)

Zhang, Z., Leir, S-H., Harris, A. (2013) Immune mediators regulate CFTR expression through an airway-selective enhancer. Molec. Cell. Biol. 33:2843-53. Epub 2013 May 20.

Yigit, E., Bischof, J.M., Zhang, Z., Ott, C.J, Kerschner, J.L., Zhang, Q., Wang, J-PZ., Widom, J., Harris, A. (2013) Nucleosome mapping across the CFTR locus identifies novel regulatory factors. Nucleic Acids Res. 41:2857-2868. Epub 2013 Jan 15.

Gosalia N, Leir SH, Harris A. Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. J Biol Chem. 2013 Mar 1;288(9):6717-25.

2012

Gillen, A.E., Harris, A. Transcriptional regulation of CFTR gene expression. Front Biosci (Elite Ed). 2012 Jan 1

Ott, CJ, Bischof, JM, Unti, KM, Gillen, AE, Leir, S-H, Harris, A. (2012) Nucleosome occupancy reveals regulatory elements of the CFTR promoter. Nucleic Acids Res 40: 625-37.

Kerschner, J.L., Harris, A. (2012) Transcriptional networks driving enhancer function in the CFTR gene. Biochem J. 446:203–212 Epub 2012 Jun 6

Zhang Z, Ott CJ, Lewandowska MA, Leir SH, Harris A. Molecular mechanisms controlling CFTR gene expression in the airway. J Cell Mol Med. 2012
Jun;16(6):1321-30.

Bischof, J.M., Ott, C.J., Leir, S-H., Gosalia, N., Song, L., London, D., Furey, T.S., Cotton, C.U., Crawford, G.E., Harris, A. A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function. Thorax. 2012 May;67(5):385-91.

Mutolo, M.J., Morris, K.J., Leir, S.H., Caffrey, T.C., Lewandowska, M.A., Hollingsworth, M.A., Harris, A. Tumor suppression by collagen XV is independent of the restin domain. Matrix Biol. 2012 Jun;31(5):285-9.

2011

Ott, C.J., Harris, A. Genomic approaches to studying CFTR transcriptional regulation. Methods Mol Biol. 2011;741:193-209.

Gillen, A.E., Harris, A. The role of CTCF in coordinating the expression of single gene loci. Biochem Cell Biol. 2011 Oct; 89(5):489-94. Epub 2011 Sep 14.

Gillen AE, Gosalia N, Leir SH, Harris A. MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene. Biochem J. 2011 Aug 15;438(1):25-32.

Ott, C.J., Harris, A. Genomic approaches for the discovery of CFTR regulatory elements. Transcription. 2011 Jan-Feb;2(1):23-7.

Leir, S-H., Harris, A. (2011) MUC6 mucin expression inhibits tumour cell invasion. Exp. Cell Res. 317:2408-2419.

2010

Lewandowska, M.A., Costa, F., Bischof, J.M., Williams, S.H., Soares, M.B., and Harris, A. (2010) Multiple Mechanisms Influence Regulation of the Cystic Firbrosis Transmembrane Conductance Regulator Gene Promoter. Am J Respir Cell Mol Bio. 43(3): 334-41.