Translational and Preclinical Services

Proliferation and Apoptosis Assays

More than 200 cell lines are available for in vitro testing, including for determination of drug IC50 values. DTC is also able to assess the effects of therapeutics on cells grown in 3D culture or on organoid cultures.

Therapy-Response Experiments

Core personnel provide expert guidance in determining the most appropriate models for evaluating the anti-cancer activities of compounds and biologicals of interest. Services include experimental design consultation, animal procurement, inoculating mice with the cells obtained from culture or from PDX, therapy administration to animals, and monitoring tumor growth and response to treatment.

Exploratory PK and Tox

Exploratory pharmacokinetics analysis can be incorporated into therapy-response experiments through organ and tissue harvest of treated animal subjects at pre-determined time points during treatment. Many DTC projects require and include determination of therapeutic maximum tolerated dose (MTD) prior to initiating a therapy-response experiment with 7-day Repeated Dose also offered.

PDX models accessible through the core

PDX models offer the closest approximation to the clinical setting for testing cancer therapies, other than immunotherapies.  Consider working with us and our Patient-Derived Xenograft Tumor Repository to help translate your research.

Collaborate with the Core

Looking for expertise?  Want access to advanced, preclinical animal models of disease?  Our lab is here to help.

FY18 Core Facility Pricing

In Vitro Services

Service LCC Investigators Northwestern
and CBC
External Academic
Cell Lines
Per Line/Availability
$247.50 $275 $300.00
Proliferation Assay
1 cell line, 1 compound
$90 $100
Proliferation Assay
up to 5 concentrations
$337.50 $375 $385.00
Spheroid Assay  $1,242 $1,380

In Vivo Services

Service LCC Investigators Northwestern and CBC External Academic
Per animal.
$270 $300 $350
Per animal.
$67.50 $75 $150
Per animal.
$40.50 $45 $50
Tumor Model Efficacy
Cell line xenograft, n=40
dosing and report included
$1,710 $1,900 $2,200
PDX Model Efficacy
PDX, n=40
dosing and report included
$1,890 $2,100 $2,200
Xenograft Setup $117 $130 $150


Service LCC Investigators Northwestern and CBC External Academic
Per hour.
$117 $130 $150
Protocol Creation ACUC. $500 $500
Per shipment.
$65 $65 $65