Department of Molecular Biosciences
Metalloregulatory proteins
The O’Halloran laboratory is exploring the cell and molecular biology of transition elements. One of our approaches is to isolate novel receptors and characterize their function, structure and chemical mechanism. In other strategies, we are interrogating the vesicular trafficking of these elements by developing vital fluorescent probes that are specific for metal ions such as Zn(II). Together, these types of experiments are delineating elemental aspects of microbial and mammalian biology